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Neurology:可能的REM睡眠行为障碍与卒中风险!

2017-04-10 xing.T MedSci原创

由此可见,存在pRBD与卒中发生风险增加有关,包括缺血性和出血性卒中类型。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估社区人群可能的REM睡眠行为障碍(pRBD)是否与脑卒中风险增加相关。

该研究纳入了12003名(平均年龄54岁)开滦研究的参与者,在招募之初(2012年),这些参与者无中风、癌症、帕金森病、老年痴呆症和脑损伤等疾病。研究人员在2102年通过使用REM睡眠行为障碍(RBD)问卷调查确定了pRBD。发生卒中的病例是通过审查病历来证实的。研究人员使用Cox比例风险模型估计了根据pRBD状态确定的卒中风险比(HR)和95%可信区间(CI),调整了一些睡眠指标(如失眠、嗜睡、睡眠时间、打鼾、使用安眠药情况)和其他潜在的混杂因素。

在3年的随访中,研究人员记录了159例卒中病例。相对于在招募之初没有pRBD的参与者,那些有pRBD的参与者发生卒中的风险增加了157%(95%CI为59%-313%)。并且那些有pRBD的参与者两种类型卒中的发生风险均有所增加,其中缺血性卒中调整后的HR为1.93(95%CI为1.07-3.46),而出血性卒中调整后的HR为6.61(95%CI为2.27-19.27)。

由此可见,存在pRBD与卒中发生风险增加有关,包括缺血性和出血性卒中类型。

原始出处:

Chaoran Ma, et al. Probable REM sleep behavior disorder and risk of stroke. Neurology. 2017.http://www.neurology.org/content/early/2017/04/07/WNL.0000000000003902.short

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    2017-04-15 yinhl1978
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    2018-01-19 tongyongming
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    2017-04-17 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1999869, encodeId=7c6819998694c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Apr 15 18:46:00 CST 2017, time=2017-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709761, encodeId=a77f1e0976150, content=<a href='/topic/show?id=3c0e90045ac' target=_blank style='color:#2F92EE;'>#行为障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90045, encryptionId=3c0e90045ac, topicName=行为障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=895a31785550, createdName=12498cb5m23暂无昵称, createdTime=Sat Sep 09 11:46:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752227, encodeId=52d41e52227f2, content=<a href='/topic/show?id=28a915303ec' target=_blank style='color:#2F92EE;'>#REM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15303, encryptionId=28a915303ec, topicName=REM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78bc36479935, createdName=tongyongming, createdTime=Fri Jan 19 22:46:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188093, encodeId=36ad188093c7, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Apr 17 07:24:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281242, encodeId=d35d128124266, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Apr 12 06:46:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186434, encodeId=d6a7186434a1, content=优质资源,大家共享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Mon Apr 10 15:53:55 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1999869, encodeId=7c6819998694c, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Apr 15 18:46:00 CST 2017, time=2017-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709761, encodeId=a77f1e0976150, content=<a href='/topic/show?id=3c0e90045ac' target=_blank style='color:#2F92EE;'>#行为障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90045, encryptionId=3c0e90045ac, topicName=行为障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=895a31785550, createdName=12498cb5m23暂无昵称, createdTime=Sat Sep 09 11:46:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752227, encodeId=52d41e52227f2, content=<a href='/topic/show?id=28a915303ec' target=_blank style='color:#2F92EE;'>#REM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15303, encryptionId=28a915303ec, topicName=REM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78bc36479935, createdName=tongyongming, createdTime=Fri Jan 19 22:46:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188093, encodeId=36ad188093c7, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Apr 17 07:24:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281242, encodeId=d35d128124266, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Apr 12 06:46:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186434, encodeId=d6a7186434a1, content=优质资源,大家共享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Mon Apr 10 15:53:55 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-10 九九消寒

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