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Cell:要想记忆好 睡眠不可少

2015-06-16 佚名 生物谷

近日,来自佛罗里达的Scripps研究所(TSRI)的研究人员们发现,睡眠可以抑制一些促进遗忘的神经细胞的活性,从而确保记忆得以保存。此项研究在线发表于Cell杂志上。 早前的研究认为,睡眠促进了记忆的保留,这个过程是通过阻止了一些来源于心理和行为活动的干扰。也就是说,睡眠可以将大脑与所有可以干扰记忆储存的刺激隔离开来。而此项最新的研究证明,睡眠促进记忆力保留是通过提高巩固记忆的能力。

近日,来自佛罗里达的Scripps研究所(TSRI)的研究人员们发现,睡眠可以抑制一些促进遗忘的神经细胞的活性,从而确保记忆得以保存。此项研究在线发表于Cell杂志上。

早前的研究认为,睡眠促进了记忆的保留,这个过程是通过阻止了一些来源于心理和行为活动的干扰。也就是说,睡眠可以将大脑与所有可以干扰记忆储存的刺激隔离开来。而此项最新的研究证明,睡眠促进记忆力保留是通过提高巩固记忆的能力。

研究人员们利用果蝇作为动物实验模型,他们发现了早前研究的生物学基础,即神经递质多巴胺的活性。多巴胺的活性可以调节多种"可塑性",例如,大脑学习和记忆的能力,及遗忘的能力。研究发现,用促进睡眠的药物Gaboxadol,或者是利用遗传方式刺激睡眠的神经回路,来增加睡眠,均可以降低多巴胺的信号活性,同时可以提高记忆力。反过来,如果增加清醒状态,刺激多巴胺的信号,则可以加速遗忘过程。这种信号活性不是一成不变的,而是与动物的清醒状态紧密相关。

研究人员们表示,睡眠对记忆保留及遗忘的能力,可能是同时进行的,而且是互不干扰的;也有可能更为复杂,有一系列的先后顺序,例如,先有遗忘能力的下降,接着是记忆能力的提高。

通过此项研究,科学家们发现了睡眠可以保护记忆的一种方式,即通过抑制可引起遗忘的多巴胺的神经活性。由于动物和人类均需要睡眠,且均有许多学习和记忆的基因和神经回路机制,所以,在果蝇动物模型上的发现,可以为研究人类睡眠与记忆的关系,提供有用的理论基础。


原始出处:

Jacob A. Berry, Isaac Cervantes-Sandoval, Molee Chakraborty, Ronald L. Davis.Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting.Cell, June 11, 2015.DOI: http://dx.doi.org/10.1016/j.cell.2015.05.027

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1869141, encodeId=b66a1869141f9, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Oct 21 19:05:00 CST 2015, time=2015-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959395, encodeId=c56e1959395c9, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Sep 29 03:05:00 CST 2015, time=2015-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29318, encodeId=87442931812, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=6, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:28:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27837, encodeId=2ec02e837c2, content=有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Tue Jun 16 21:24:00 CST 2015, time=2015-06-16, status=1, ipAttribution=)]
    2015-09-29 维他命
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    2015-06-25 huaxipanxing

    看看

    0

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    2015-06-16 zhouanxiu

    有益

    0

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