Front Immunol：研究揭示了结核病治疗的新靶点

2018-05-16 MedSci MedSci原创

结核分枝杆菌是结核病（TB）的病原体，主要引起肺损伤和结节。尽管通常认为巨噬细胞是携带结核分枝杆菌的主要细胞，但新的证据表明嗜中性粒细胞迅速募集到受感染的肺部。结核分枝杆菌本身或其早期分泌的抗原靶蛋白6（ESAT-6）可以诱导嗜中性粒细胞胞外诱集剂（NETs）的形成。然而，NETs仅能捕获却无法杀死分枝杆菌，其在分枝杆菌发病机制中的作用尚不清楚。在这里，我们报告了一种新的结核分枝杆菌细胞外因子，双

结核分枝杆菌是结核病（TB）的病原体，主要引起肺损伤和结节。尽管通常认为巨噬细胞是携带结核分枝杆菌的主要细胞，但新的证据表明嗜中性粒细胞迅速募集到受感染的肺部。结核分枝杆菌本身或其早期分泌的抗原靶蛋白6（ESAT-6）可以诱导嗜中性粒细胞胞外诱集剂（NETs）的形成。然而，NETs仅能捕获却无法杀死分枝杆菌，其在分枝杆菌发病机制中的作用尚不清楚。在这里，我们报告了一种新的结核分枝杆菌细胞外因子，双功能酶Rv0888，同时具有核酸酶和鞘磷脂酶活性。

Rv0888鞘磷脂酶活性可诱导小鼠体外和肺内NETs的形成，并增强耻垢分枝杆菌在小鼠肺中的定植能力。携带Rv0888鞘磷脂酶的耻垢分枝杆菌感染的小鼠通过Rv0888鞘磷脂酶，相关蛋白触发的半胱天冬酶-3诱导，主要由NETs介导的肺的病理损伤和炎症。

总之，这项研究揭示了分枝杆菌发病机制的新亮点，并揭示了TB治疗的新靶点。

原始出处：

Guanghui Dang, Yingying Cui, et al., Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps. Front Immunol. 2018; 9: 677. doi: 10.3389/fimmu.2018.00677

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#插入话题

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2018-05-18 huhuaidong387

#结核#

64 0
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2018-05-18 lsndxfj

#新靶点#

80 0
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2018-05-17 龙胆草

学习谢谢分享

105 0
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2018-05-17 飛歌

学习了很有用

93 0
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2018-05-17 12225669m29暂无昵称

学习

90 0
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2018-05-17 1209e435m98(暂无昵称)

学习了.谢谢分享

85 0
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2018-05-17 1dd8c52fm63(暂无匿称)

了解了解.学习学习

93 0
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2018-05-17 yjs木玉

学习学习再学习

55 0

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