年度成就得主马骏教授：手把手教你发NEJM：CSCO2019

2019-09-21 不详 MedSci原创

第22届全国临床肿瘤学大会暨2019年CSCO学术年会于9月19日开幕，本届大会将2019年度成就奖颁发给了中山大学肿瘤防治中心马骏教授团队的“在局部晚期鼻咽癌患者中，同期放化疗前，吉西他滨+顺铂诱导化疗的III期、多中心、随机对照研究”。此次获奖研究内容发表于新英格兰医学期刊（The New England Journal of Medicine；简称NEJM）杂志，同时也被选为2019年

第22届全国临床肿瘤学大会暨2019年CSCO学术年会于9月19日开幕，本届大会将2019年度成就奖颁发给了中山大学肿瘤防治中心马骏教授团队的“在局部晚期鼻咽癌患者中，同期放化疗前，吉西他滨+顺铂诱导化疗的III期、多中心、随机对照研究”。

此次获奖研究内容发表于新英格兰医学期刊（The New England Journal of Medicine；简称NEJM）杂志，同时也被选为2019年的“Best of ASCO”。

在大会上，马骏教授向我们分享了他的NEJM投稿心得。

1.方案设计获认可

方案设计科学，有助于审稿顺利。

主要体现在几个方面：

·GP方案的选择：有前期结果

·对照组：标准治疗

·试验设计：随机对照，可信度高

·样本量计算：合理

·统计方法：严谨、遵循杂志要求

·数据解读：客观

2.统计方法要科学

NEJM不同于其他杂志，统计学要求严格，有两篇统计要求综述可参考。

（1）P值

除主要研究终点外，其余统计分析均不使用P值。两篇NEJM综述认为，很多临床研究文章中P值被过度滥用。因此在投稿NEJM时应特别小心P值的使用，符合杂志要求。

（2）生存分析

常用：单因素+多因素分析，而NEJM目前要求统一使用校正单因素分析。

（3）亚组分析

NEJM不主张进行亚组分析，研究主要看主要终点的比较，如用亚组分析比较，会有很多混杂因素，得出的结果可能会不可靠、不科学。

可利用森林图展示亚组分析结果，将亚组分析材料放在附件中作为参考。列出结果的置信区间，无需P值。

3.文字表达需简洁

主编及副主编亲自改稿，注重风格简洁，原论文题目为24词，被修改至8个词。投稿时应注意文字表达。

4.时间紧迫要合作

从投稿到接受仅30天，连续多次修回，每轮时限三四天。

可通过团队配合分工，减省时间。

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在此留言

评论区 (5)

#插入话题

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2021-08-19 ms9000001748316827

学习学习

106 0
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2020-04-08 12498c24m76暂无昵称

#马骏#

92 0
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2020-06-09 heli0118

#马骏教授#

69 0
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2019-09-23 1209e435m98(暂无昵称)

学习了，谢谢分享

137 0
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2019-09-21 旺医

顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息

85 0

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