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Stroke: ICH后白细胞升高与血肿扩大减少相关

2016-07-24 phylis 译 MedSci原创

背景:急性白细胞增多是急性脑出血(ICH)的一种反应。白细胞,因为它们与血小板和凝血因子的相互作用,可能会在止血中发挥作用。研究者调查入院白细胞增多是否与急性脑出血后出血减少相关。方法:前瞻性收集从1994至2015原发性脑出血的患者,对其进行回顾性分析。研究包括随访中的CT扫描和症状开始后48小时内的白细胞计数。应用半自动软件计算基线和随访中的血肿体积,血肿扩大定义为体积增大>30%或6mL。应

背景:急性白细胞增多是急性脑出血(ICH)的一种反应。白细胞,因为它们与血小板和凝血因子的相互作用,可能会在止血中发挥作用。研究者调查入院白细胞增多是否与急性脑出血后出血减少相关。

方法:前瞻性收集从1994至2015原发性脑出血的患者,对其进行回顾性分析。研究包括随访中的CT扫描和症状开始后48小时内的白细胞计数。应用半自动软件计算基线和随访中的血肿体积,血肿扩大定义为体积增大>30%或6mL。应用多因素Logistic回归分析调查血白细胞计数与脑出血血肿扩大的相关性。

结果:共有1302名受试者符合资格标准(平均年龄为75岁;55.8%为男性),其中207例(15.9%)有血肿扩大。入院时高白细胞计数与血肿扩大风险减少相关(每增加1000细胞的OR : 0.91;95%CI,0.86-0.96)。血肿扩大的风险与中性粒细胞计数呈负相关(OR,0.90;95%CI,0.85-0.96;P = 0.001),和单核细胞计数直接相关(OR,2.71;95%CI,1.08-6.83;)。淋巴细胞计数和ICH血肿扩大没有明显相关性(OR,0.96;95%CI,0.79-1.17)。

结论:较高的入院白血细胞计数与血肿扩张的风险较低相关。研究结果强调急性ICH后,炎症反应在调节凝血级联反应中的作用。

原始出处:

Morotti A, Phuah CL, et al. Leukocyte Count and Intracerebral Hemorrhage Expansion. Stroke. 2016 Jun.


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  2. [GetPortalCommentsPageByObjectIdResponse(id=1709747, encodeId=f33e1e097474b, content=<a href='/topic/show?id=a329899025a' target=_blank style='color:#2F92EE;'>#血肿扩大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89902, encryptionId=a329899025a, topicName=血肿扩大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b7f31781183, createdName=ms1774076774505970, createdTime=Sat May 13 18:17:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145414, encodeId=1b6f1454146b, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:19:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316339, encodeId=78ce131633990, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394910, encodeId=ca4a139491039, content=<a href='/topic/show?id=be548989e09' target=_blank style='color:#2F92EE;'>#血肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89897, encryptionId=be548989e09, topicName=血肿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文,值得推荐。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1709747, encodeId=f33e1e097474b, content=<a href='/topic/show?id=a329899025a' target=_blank style='color:#2F92EE;'>#血肿扩大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89902, encryptionId=a329899025a, topicName=血肿扩大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b7f31781183, createdName=ms1774076774505970, createdTime=Sat May 13 18:17:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145414, encodeId=1b6f1454146b, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:19:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316339, encodeId=78ce131633990, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394910, encodeId=ca4a139491039, content=<a href='/topic/show?id=be548989e09' target=_blank style='color:#2F92EE;'>#血肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89897, encryptionId=be548989e09, topicName=血肿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]
    2016-07-26 diushouji
  4. [GetPortalCommentsPageByObjectIdResponse(id=1709747, encodeId=f33e1e097474b, content=<a href='/topic/show?id=a329899025a' target=_blank style='color:#2F92EE;'>#血肿扩大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89902, encryptionId=a329899025a, topicName=血肿扩大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b7f31781183, createdName=ms1774076774505970, createdTime=Sat May 13 18:17:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145414, encodeId=1b6f1454146b, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:19:49 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316339, encodeId=78ce131633990, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394910, encodeId=ca4a139491039, content=<a href='/topic/show?id=be548989e09' target=_blank style='color:#2F92EE;'>#血肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89897, encryptionId=be548989e09, topicName=血肿)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85df2500173, createdName=654699882_84926986, createdTime=Tue Jul 26 00:17:00 CST 2016, time=2016-07-26, status=1, ipAttribution=)]

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