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Mol Med Rep：全转录调控分析为乳腺癌的治疗提供新的生物标志物

2017-11-11 MedSci MedSci原创

乳腺癌转录调控
关注

非编码RNA在调节某些基因的表达中起重要作用，并参与了乳腺癌的发生发展。绝大多数研究都集中在探究发现调控和发挥功能的非编码RNAs（lncRNAs）和微小RNAs（miRNAs/miRs），很少有研究调查了lncRNAs和miRNAs的转录调节。本研究中，基于TCGA数据库浸润性乳腺癌的癌基因组数据，并使用生物信息学计算方法，构建了一个lncRNA- miRNA- mRNA网络。该网络由601个节

非编码RNA在调节某些基因的表达中起重要作用，并参与了乳腺癌的发生发展。绝大多数研究都集中在探究发现调控和发挥功能的非编码RNAs（lncRNAs）和微小RNAs（miRNAs/miRs），很少有研究调查了lncRNAs和miRNAs的转录调节。

本研究中，基于TCGA数据库浸润性乳腺癌的癌基因组数据，并使用生物信息学计算方法，构建了一个lncRNA- miRNA- mRNA网络。该网络由601个节点和706个边缘，代表lncRNA-、miRNA以及靶基因之间的复杂的调控网络。目前的研究表明，mir-510是最有力的miRNA，是许多靶基因的调节控制器。此外，据观察，lncRNAs PVT1、CCAT1和linc00861与临床生物标志物相互作用，包括受体酪氨酸蛋白激酶erbB-2、雌激素受体和孕激素受体，且已经RNA蛋白相互作用预测软件演示证明。

总之，该研究结果表明，lncRNA-miRNA- mRNA相互作用将会行进一步的实验研究，或可用于乳腺癌的治疗中开发新的生物标志物预测。

原始出处：

Yuhan Zhang, Yongfeng Li, et al., Identification of an lncRNA-miRNA-mRNA interaction mechanism in breast cancer based on bioinformatic analysis. Mol Med Rep. 2017 Oct; 16(4): 5113–5120. Published online 2017 Aug 21. doi: 10.3892/mmr.2017.7304

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    2018-07-12 crystal0562

    #转录调控#

    0

  2. 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    2018-09-09 hukaixun

    #标志物#

    0

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time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260834, encodeId=4e0c26083457, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 12 19:16:01 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-23 虈亣靌

    好好学习努力向上

    0

  4. 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time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260834, encodeId=4e0c26083457, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 12 19:16:01 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-22 jyzxjiangqin

    全转录调控分析.

    0

  5. 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time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260834, encodeId=4e0c26083457, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 12 19:16:01 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2018-06-24 mjldent

    #转录#

    0

  6. 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time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260834, encodeId=4e0c26083457, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 12 19:16:01 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-17 虈亣靌

    好消息.值得学习

    0

  7. 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href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608229, encodeId=1f10160822901, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260834, encodeId=4e0c26083457, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 12 19:16:01 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-13 zhu_jun9842

    #生物标志#

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 17 16:55:53 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560685, encodeId=2bb2156068573, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566694, encodeId=491715666946d, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608229, encodeId=1f10160822901, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260834, encodeId=4e0c26083457, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 12 19:16:01 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-13 zhu_jun9842

    #生物标志#

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Nov 17 16:55:53 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560685, encodeId=2bb2156068573, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566694, encodeId=491715666946d, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608229, encodeId=1f10160822901, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Nov 13 01:43:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260834, encodeId=4e0c26083457, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Nov 12 19:16:01 CST 2017, time=2017-11-12, status=1, ipAttribution=)]
    2017-11-13 ms3994565386320060

    #Med#

    0

  10. 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    2017-11-12 虈亣靌

    优质资源.共同学习

    0

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目前已知，慢性炎症与癌症的发展密切相关。作为一项简单的无创血液检测，常规血液检查中的血液学参数可看做是炎症标志物。本研究旨在评估血小板计数（PC），红细胞分布宽度（RDW），白细胞计数（WBC），平均血小板体积（MPV），中性粒细胞/淋巴细胞比例（NLR）和血小板计数/淋巴细胞比率（PLR）作为乳腺癌（BC）患者的替代炎性标志物，然后将其与健康个体进行比较。2014年7月至2015年4月在武汉大学

殷咏梅对话ABC4科学委员会主席Eric Winer，为您全面解读ABC4国际共识会议

在第四届ESO-ESMO国际晚期乳腺癌共识（ABC4）会议现场，江苏省人民医院殷咏梅教授对话ABC4科学委员会主席Eric Winer教授，Winer教授介绍了ABC4共识的重要内容，CDK4/6抑制剂的应用前景，分享了他在管理CDK4/6抑制剂副作用方面的临床经验，解析了内分泌药物的最佳用药顺序等。

NEJM：警醒！科学研究发现：乳腺癌的复发风险在治疗结束后会持续数年

根据《新英格兰医学杂志》(new England Journal of Medicine)发表的一项国际调查小组的最新分析即使诊断20年后，由雌激素引起的乳腺癌类型的女性仍然面临癌症复发或扩散的实质性风险。

JAHA：乳腺癌患者蒽环类药物治疗期间神经激素阻断和循环心血管生物标志物变化！

采用当前的蒽环类抗生素剂量来治疗早期乳腺癌与循环心血管生物标志物增加有关。然而，这种增加与心室功能的早期下降无关。β-阻滞剂可能会减弱早期心肌损伤，但是这种减弱是否会降低心室功能障碍的长期风险仍然不清楚。

Trends in Cancer：科学家提倡乳腺癌单细胞诊断

近日发表在《癌症趋势》杂志上的一篇文章中，两位研究人员称，乳腺癌患者可能从其肿瘤内不同细胞的分子亚型中受益。虽然乳腺癌通常被视为一个整体进行治疗，但人们越来越对这样的理论达成共识，即肿瘤中的癌细胞可以有多个起源，并能对治疗做出不同反应。因此，作者主张开发更精确的诊断测试，以甄别肿瘤细胞间的分子不规则性。

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