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J Stroke Cerebrovasc Dis:他汀类药物能够降低LDL-C急性卒中患者的死亡率

2015-09-01 phylis 译 MedSci原创

为了调查住院患者他汀类药物治疗对低密度脂蛋白胆固醇(LDL-C<1.81 mmol/L)水平的急性卒中患者死亡率的影响。从中国国家登记表中招募急性卒中患者,患者LDL-C低于1.81 mmol/L。住院期间根据患者是否应用他汀类治疗,将患者分为他汀组和非他汀组。应用多变量二元logistic回归模型分析患者进行他汀类药物治疗和患者1年死亡率之间的关系。招募了1018名患者,3个月累积死亡率为

为了调查住院患者他汀类药物治疗对低密度脂蛋白胆固醇(LDL-C<1.81 mmol/L)水平的急性卒中患者死亡率的影响。

从中国国家登记表中招募急性卒中患者,患者LDL-C低于1.81 mmol/L。住院期间根据患者是否应用他汀类治疗,将患者分为他汀组和非他汀组。应用多变量二元logistic回归模型分析患者进行他汀类药物治疗和患者1年死亡率之间的关系。

招募了1018名患者,3个月累积死亡率为10.1%,6个月累积死亡率13.1%,1年的累积死亡率为15.9%。他汀组的死亡率低于非他汀组(3.6% versus 13.7% at 3 months; 6.2% versus 16.9% at 6 months; 8.4% versus 20% at 1 year)。Logistic分析表明住院期间,应用他汀类药物治疗与患者3个月(OR,0.35; 95% CI, 0.18-0.67),6个月(OR,0.42; 95% CI, 0.25-0.73),1年(OR,0.47; 95% CI, 0.29-0.76)的死亡率下降有关。

住院期间应用他汀类药物能够降低LDL-C急性卒中患者的死亡率。

原文出处:

Song B, Wang Y, Zhao X,et al. Inpatient Statin Use Is Associated with Decreased Mortality of Acute Stroke Patients with Very Low Low-Density Lipoprotein Cholesterol. J Stroke Cerebrovasc Dis. 2015 Aug 21. 


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    2016-03-24 quxin068
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    2015-09-03 zhwj

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