Heart：达比加群对导管消融房颤患者安全性与华法林相当

2013-07-29 高晓方译 cmt

法国一项荟萃分析表明，在接受导管消融的房颤患者中，达比加群治疗者的血栓栓塞事件和大出血发生率与华法林相当，总体事件发生率低。论文于7月22日在线发表于《心脏》（Heart）。研究者检索了Medline、Embase和Cochrane数据库，并纳入了在接受导管消融治疗的阵发性/持续性房颤患者中比较达比加群和华法林的对照试验。从纳入研究中提取围手术期全因死亡、血栓栓塞性事件和大出血等描述性和定

法国一项荟萃分析表明，在接受导管消融的房颤患者中，达比加群治疗者的血栓栓塞事件和大出血发生率与华法林相当，总体事件发生率低。论文于7月22日在线发表于《心脏》（Heart）。

研究者检索了Medline、Embase和Cochrane数据库，并纳入了在接受导管消融治疗的阵发性/持续性房颤患者中比较达比加群和华法林的对照试验。从纳入研究中提取围手术期全因死亡、血栓栓塞性事件和大出血等描述性和定量信息。

结果显示，共有包括4782例患者的14项研究符合纳入标准，其中达比加群和华法林治疗者分别为1823和2959例。未报告死亡。接受达比加群和华法林治疗的患者在血栓栓塞性事件（危险比[RR] 1.78；P=0.26）和大出血（RR 1.07；P=0.86）方面无显著差异。达比加群110 mg和150 mg 2次/日在大出血（P=0.25）和血栓栓塞（P=0.82）方面亦无显著差异。

Providência R, Albenque JP, Combes S, Bouzeman A, Casteigt B, Combes N, Narayanan K, Marijon E, Boveda S.Safety and efficacy of dabigatran versus warfarin in patients undergoing catheter ablation of atrial fibrillation: a systematic review and meta-analysis.Heart. 2013 Jul 22.

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#插入话题

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2014-05-26 医者仁心

#患者安全#

68 0
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2013-07-31 zhaojie88

#ART#

56 0
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2013-07-31 wjcjjian

#导管消融#

69 0
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2013-07-31 xiangyuzhou972

#消融#

57 0
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2013-07-31 slcumt

#HEART#

70 0
[GetPortalCommentsPageByObjectIdResponse(id=2045111, encodeId=d49e2045111fe, content=<a href='/topic/show?id=a0555302119' target=_blank style='color:#2F92EE;'>#患者安全#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53021, encryptionId=a0555302119, topicName=患者安全)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon May 26 09:56:00 CST 2014, time=2014-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355782, encodeId=0d481355e8201, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Jul 31 07:56:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399580, encodeId=890d1399580bb, content=<a href='/topic/show?id=9a0546e31b5' target=_blank style='color:#2F92EE;'>#导管消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46731, encryptionId=9a0546e31b5, topicName=导管消融)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd042221840, createdName=wjcjjian, createdTime=Wed Jul 31 07:56:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421571, encodeId=dcb214215e1b7, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Wed Jul 31 07:56:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562179, encodeId=9c4f15621e96b, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Jul 31 07:56:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614221, encodeId=908f161422161, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Wed Jul 31 07:56:00 CST 2013, time=2013-07-31, status=1, ipAttribution=)]
2013-07-31 hittouch

#房颤患者#

61 0

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