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NEJM:类风湿关节炎患者的伸缩式手指-病例报道

2019-12-12 xing.T MedSci原创

患者接受托法替尼、甲氨蝶呤、小剂量泼尼松和伊班膦酸治疗,疼痛和肿胀有所减轻,但并未改变手部功能。

患者为一名69岁的妇女,因严重的关节畸形而到风湿病科就诊。她在18年前被诊断为类风湿关节炎,该病对糖皮质激素、甲氨蝶呤、来氟米特、阿达木单抗、依那西普、阿巴西普和利妥昔单抗的各种药物治疗均难以治愈。

体格检查显示双手尺骨偏斜。双手、腕部、肘部、膝盖和左脚踝的掌指关节有压痛和肿胀。双手检查还显示出手指缩短,活动性手指弯曲受限和无法握拳。施加在手指远端的牵引力使手指得以拉伸,并且当松开时,手指回到其原始位置。



手部X光片显示尺骨远端和桡骨以及腕骨、掌骨和指骨出现严重的骨溶解。观察到的伸缩现象是这种骨吸收的结果。

患者接受托法替尼、甲氨蝶呤、小剂量泼尼松和伊班膦酸治疗,疼痛和肿胀有所减轻,但并未改变手部功能。  

原始出处:

Hasan Satis,et al.Telescoping Fingers in Rheumatoid Arthritis.N Engl J Med 2019;https://www.nejm.org/doi/full/10.1056/NEJMicm1905982

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    2019-12-13 lmm397
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    2019-12-12 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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