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APJCN:马来西亚2型糖尿病人膳食升糖指数与血浆脂联素浓度相关

2013-11-20 佚名 亚太临床营养杂志

脂肪细胞衍生的激素-脂联素,被认为会调控2型糖尿病患者之血糖浓度及慢性发炎反应。然而,仅有限的研究评估饮食因子对血浆中脂联素浓度的影响,更缺少针对马来西亚2型糖尿病患者的研究。本研究的目的在于评估膳食升糖指数对于2型糖尿病患者血浆脂联素的影响。 此横断面研究,受试者为305位,于马来西亚槟城总医院就医,年龄介于19-75岁的2型糖尿病患者。使用标准化问卷搜集社会人口学


脂肪细胞衍生的激素-脂联素,被认为会调控2型糖尿病患者之血糖浓度及慢性发炎反应。然而,仅有限的研究评估饮食因子对血浆中脂联素浓度的影响,更缺少针对马来西亚2型糖尿病患者的研究。本研究的目的在于评估膳食升糖指数对于2型糖尿病患者血浆脂联素的影响。【原文下载】

此横断面研究,受试者为305位,于马来西亚槟城总医院就医,年龄介于19-75岁的2型糖尿病患者。使用标准化问卷搜集社会人口学信息,膳食评估则使用具效度的半定量食物频率问卷。体位测量包括体重、身高、身体质量指数及腰围。血浆脂联素浓度是使用市售的酵素结合免疫吸附(ELISA)试剂组检测。统计方法为多元线性回归。校正多变项后,膳食升糖指数与血浆脂联素浓度呈显著负相关(β= -0.272;95%CI:-0.262, -0.094;p<0.001)。个体每摄取一单位高升糖指数之食品,血浆脂联素下降0.3 g/mL.依据多元线性回归模式(R2=0.319),血浆脂联素浓度31.9%的变异量可由年龄、性别、种族、抽烟、身体质量指数、腰围、高密度脂蛋白胆固醇、三酸甘油酯、镁、膳食纤维及升糖指数所解释。

这些结果证实,膳食升糖指数会影响2型糖尿病患者血浆中脂联素的浓度。对于此结果的验证以及可能机制的阐明,仍需要临床试验进一步厘清。

原文出处:

Beng-In Loh, Daniel Robert Sathyasurya, Hamid Jan Jan Mohamed.Plasma adiponectin concentrations are associated with dietary glycemic index in Malaysian patients with type 2 diabetes.Asia Pac J Clin Nutr 2013;22 (2):241-248.【原文下载】

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