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JAMA Intern Med:收缩压高的高血压患者心血管事件风险较高

2014-06-24 小田 编译 医学论坛网

美国学者们探索了不同高血压水平成人的突发心血管事件风险,结果表明,收缩压升高的高血压患者心血管事件风险最高,但在这一分类分析中,与收缩压降至140 mm Hg相比,收缩压低于120 mm Hg似乎并不减少突发心血管事件风险。论文6月16在线发表于《美国医学会杂志·内科学》(JAMA Intern Med)。 该研究共纳入动脉粥样硬化风险社区研究的4480例高血压但基线无心血管疾病的受试

美国学者们探索了不同高血压水平成人的突发心血管事件风险,结果表明,收缩压升高的高血压患者心血管事件风险最高,但在这一分类分析中,与收缩压降至140 mm Hg相比,收缩压低于120 mm Hg似乎并不减少突发心血管事件风险。论文6月16在线发表于《美国医学会杂志·内科学》(JAMA Intern Med)。

该研究共纳入动脉粥样硬化风险社区研究的4480例高血压但基线无心血管疾病的受试者。检测受试者基线收缩压和每3年对其进行随访,以时间-依赖变量控制收缩压,将血压分成升高(≥140 mm Hg)、标准(120-139 mm Hg)和低水平(<120 mm Hg)三类。多变量Cox回归模型包括基线年龄、性别、糖尿病、体质指数(BMI)、高水平的胆固醇水平、吸烟和酒精摄入。以突发复合心血管事件(心力衰竭、缺血性卒中、心肌梗死或冠心病相关的死亡)为主要转归。

结果显示,在中位随访21.8年后,共发生1622次突发心血管事件。与低血压组相比,收缩压升高的受试者心血管事件发生率显著较高(校正危险比为1.46)。但标准血压组和低水平收缩压组的突发心血管事件生存无差异(校正危险比1.00)。进一步调整降压药的应用或舒张压并未显著影响结果。

原始出处:


Rodriguez CJ1, Swett K1, Agarwal SK2, Folsom AR3, Fox ER4, Loehr LR5, Ni H6, Rosamond WD5, Chang PP5.Systolic Blood Pressure Levels Among Adults With Hypertension and Incident Cardiovascular Events: The Atherosclerosis Risk in Communities Study.JAMA Intern Med. 2014 Jun 16. doi: 10.1001/jamainternmed.2014.2482.

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