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Ann Rheum Dis:慢性炎症性疾病中的常见精神障碍

2019-03-11 xiangting MedSci原创

炎性疾病的初级治疗患者中抑郁和焦虑的发病率升高,特别是那些早发性炎性疾病患者。

关于初级治疗背景下炎症性疾病与抑郁和焦虑发作之间关联的证据存在不一致。这项研究旨在评估多系统和器官特异性炎性疾病中抑郁和焦虑的风险。

这是一项前瞻性队列研究,纳入来自英国临床实践研究数据链的初级治疗患者,这些患者于2001年1月1日至2016年12月31日期间被诊断为炎性疾病。这些患者根据年龄、性别、实践和指数日期与无炎性疾病的患者相匹配。研究暴露是7种慢性炎性疾病。临床诊断为抑郁和焦虑代表了感兴趣的结局指标。

在538707名参与者中,抑郁症的发病率从每1000人年14(严重银屑病)到每1000人年9(系统性血管炎),与对照组比较(每1000人年5-7)实质上更高。与匹配的对照组相比,炎性疾病中多种抑郁和焦虑事件的HRs高16%(HR,1.16,95%CI 1.12至1.21,p<0.001)。抑郁、焦虑的发病率与炎性疾病的起病年龄密切相关。早发性疾病中(<40岁)抑郁症的总体HR估算为1.90(95%CI 1.66至2.17,p<0.001),晚发性疾病中(≥60岁)为0.93(95%CI 0.90至1.09,p=0.80)。

炎性疾病的初级治疗患者中抑郁和焦虑的发病率升高,特别是那些早发性炎性疾病患者。尽管确切机制仍需要进一步研究,这一发现可能反映了潜在疾病对患者生活质量的影响。

原始出处:

Alexandru Dregan. Common mental disorders within chronic inflammatory disorders: a primary care database prospective investigation. Ann Rheum Dis. 07 March 2019.

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