Baidu
map

郭艺芳:大多数心血管病患者适于中等强度他汀治疗

2015-06-25 郭艺芳 郭艺芳微博

——解析美国VA血脂管理指南河北省人民医院 郭艺芳近日,美国退伍军人管理局等机构颁布了“降脂治疗降低心血管病风险临床实践指南”(以下简称“VA指南”)。全文发表于Ann Intern Med 。就学术地位而言,这一指南并无很大学术影响力。然而,因为VA指南发表于备受争议的2013年美国成人降胆固醇指南之后,其立场观点受到很多学者的关注。 全文下载:Management of Dyslip

——解析美国VA血脂管理指南

河北省人民医院 郭艺芳

近日,美国退伍军人管理局等机构颁布了“降脂治疗降低心血管病风险临床实践指南”(以下简称“VA指南”)。全文发表于Ann Intern Med 。就学术地位而言,这一指南并无很大学术影响力。然而,因为VA指南发表于备受争议的2013年美国成人降胆固醇指南之后,其立场观点受到很多学者的关注。


总的来看,VA指南的主要特点包括以下5方面:

1.放弃降脂治疗目标值。这一做法与2013 ACC/AHA成人降胆固醇治疗指南相一致;

2.不推荐将C反应蛋白和冠状动脉钙化积分作为心血管风险评估的常规指标;

3.进一步细化了他汀用于动脉粥样硬化性心血管病(ASCVD)一级预防的评估流程;

4.认为中等强度他汀适合于多数ASCVD患者的二级预防,这有别于2013 ACC/AHA指南。后者认为多数ASCVD患者均应选用高强度他汀(即阿托伐他汀40-80mg或瑞舒伐他汀20-40mg)治疗;

5.检验血脂参数无需空腹,且治疗前后无需常规监测血脂指标。

在上述5点建议中,关于ASCVD患者他汀治疗强度的推荐最值得关注,这是继美国国家脂质协会(NLA)指南与国际动脉粥样硬化协会(IAS)指南之后,又一美国学术机构做出了不同于2013 ACC/AHA成人降胆固醇指南的建议。

VA指南认为,先后发表的三项降胆固醇治疗试验协作组荟萃分析显示,中等强度他汀(阿托伐他汀10mg,辛伐他汀20-40mg,普伐他汀4Omg,洛伐他汀40-80mg)治疗可显著降低ASCVD患者全因死亡率、冠心病死亡率、非致死性心肌梗死和非致死性卒中发生率。因此,中等强度他汀在ASCVD患者的二级预防中具有充分的证据,应作为主要的治疗措施。虽然VA指南认为对于急性冠状动脉综合征或复发性冠心病事件的患者可以考虑使用高强度他汀治疗,但该指南明确指出这一建议的证据力度较小,并且与低强度他汀相比,使用高强度他汀治疗并不能显著降低全因死亡率与心血管死亡率,高强度他汀的获益仅限于非致死性心肌梗死或非致死性卒中发生率的降低。VA指南同时指出,高强度他汀治疗可以显著增加不良反应事件发生率以及停药率,肝酶异常与肌酸激酶增高者显著高于低剂量他汀治疗者。鉴于高强度他汀治疗的临床获益证据并不充分,因此VA指南不建议将其作为ASCVD患者的常规治疗方案。

应该说VA指南的上述推荐建议是理性客观的,充分考虑了现有的临床研究证据以及他汀治疗的获益/风险平衡,对于合理的应用他汀起到了很好的导向作用。近年来,国外一些学者主张将高强度他汀作为ASCVD患者的常规治疗方案,这一观点为我国的临床医生带来了很多困惑。

实际上,认真梳理现有证据不难发现,目前并无确凿证据支持高强度他汀治疗策略。例如,在针对急性冠状动脉综合征患者所进行的两项代表性的研究中,PROVE IT-TIMI 22显示强化他汀治疗可以显著降低主要复合心血管终点事件发生率。但进一步分析可见,其主要终点发生率的降低主要是由血运重建与不稳定心绞痛住院等“软”终点所驱动的,诸如全因死亡、冠心病死亡、心肌梗死和卒中等“硬”终点事件并未减少。

A to Z试验则发现,与标准治疗组相比,强化他汀治疗并未能显著降低主要终点事件危险性,但显著增加了肌病发生率。以TNT和IDEAL为代表的针对稳定性冠心病患者进行的强化他汀治疗试验亦同样如此:TNT研究显示强化他汀治疗组主要复合终点事件发生率显著降低,但最值得关注的“硬”终点心血管死亡率并未显著减低。而在IDEAL研究中,强化降胆固醇组患者主要终点事件发生率并未呈现统计学显著性下降。

与欧美国家人群相比,我国居民对于大剂量他汀的耐受性更差,发生不良反应的风险更高,盲目追求大剂量高强度他汀治疗既缺乏临床研究证据,也不符合我国国情。在临床实践中,应根据我国现行指南性文件的原则,结合患者心血管风险水平确定相应的LDL-C目标值,并以此为基础确定适宜的他汀治疗强度。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (27)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1644436, encodeId=8fde164443623, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Jul 27 11:32:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31186, encodeId=c5ee31186c8, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31187, encodeId=6b723118e9e, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31189, encodeId=b44731189ac, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31188, encodeId=04af3118876, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 08:00:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31181, encodeId=305431181ab, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31180, encodeId=2a62311806b, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31179, encodeId=ac9d311e9ef, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31177, encodeId=a65d311e783, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31178, encodeId=81a7311e8fe, content=还好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e880105337, createdName=famous, createdTime=Tue Jul 07 07:59:00 CST 2015, time=2015-07-07, status=1, ipAttribution=)]
    2015-07-07 famous

    还好!

    0

相关资讯

TECOS心血管安全性研究达到主要终点

(2015年6月8日,美国新泽西)默沙东公司(在美国与加拿大称为默克)宣布了"评估2型糖尿病口服药物西格列汀心血管安全性的临床研究"(TECOS)的结果。相关数据已在线发表于最新一期《新英格兰医学杂志》,并在第75届美国糖尿病学会年会上同步揭晓。 TECOS是一项随机,双盲,安慰剂对照试验,由默沙东申办,牛津大学糖尿病试验团队和杜克大学临床研究中心牵头实施。患者入组始于2008年,直至2012年

ADA 2015:DPP-4抑制剂西格列汀心血管安全性良好(TECOS研究)

TECOS研究是一项有关伴心血管疾病的2型糖尿病患者在接受常规治疗基础上,加用二肽基肽酶-4(DPP-4)抑制剂西格列汀对此类患者心血管事件影响的随机、双盲、安慰剂对照试验。其结果显示,西格列汀不增加此类患者达到心血管死亡、非致死性心梗、非致死性卒中或不稳定心绞痛住院的复合终点事件风险,也不增加心衰住院或其他不良反应事件的风险。该研究共计纳入14671例患者,在其现有治疗基础上被随机分为加用西格列

JAMIA:出生月份原来真的可以影响一个人的健康

出生月份可显著影响个体一生所患的疾病,先前的研究表明出生月份与许多疾病,包括动脉粥样硬化、哮喘、多动症以及近视有关,此外尚有许多疾病并未明确与出生月份之间的关系。本次回顾性研究的目的是为了探讨季节对个体出生和一生所患疾病的影响。

ADA 2015:阿格列汀未增加ACS患者心血管事件(EXAMINE试验)

EXAMINE试验中有关心肌缺血事件和心血管住院率的所有数据以口头报告的形式公布。EXAMINE试验评估了近期发生急性冠脉综合征的2型糖尿病患者在接受DPP-4抑制剂阿格列汀后的心血管事件。结果显示,在EXAMINE试验人群中,心肌梗死及不稳定型心绞痛、冠脉重建、心血管事件住院以及这些缺血性事件构成的复合终点的发生率普遍较高,尤其是心血管事件住院率及冠脉重建。但以上心肌缺血事件在阿格列汀组和安慰剂

J Dental Res:掉了几颗牙?看你健康不

牙齿提前脱落通常表明一个人口腔疾病的历史。芬兰赫尔辛基大学与国家卫生福利研究院的研究人员在广泛的队列研究结果后,发现牙齿提前脱落与未来心血管事件,糖尿病和死亡有关。缺牙的数目可能作为医生评估慢性疾病风险因素时的一个有用的附加指标。这篇文章发表在Journal of Dental Research。 The National FINRISK 1997研究是以芬兰人口为基础的调查。对8446位年龄在

J Dairy Sci:乳制品中的特殊蛋白或可保护机体抵御心血管疾病

美拉德反应是一种在复杂糖和氨基酸之间发生的褐变反应,当蛋白质和糖类混合在一起被加热时就会产生新的化合物,有些就会产生新的香料及其它物质,近日一篇发表在国家杂志Journal of Dairy Science上的研究论文中,来自高丽大学等处的研究人员就发现牛奶中的蛋白质可以帮助机体抵御心血管疾病的发生。 文章中研究者表示,一种在乳制品中形成的饮食化合物可以降低小鼠机体血清中总的胆固醇水平、低密度脂

Baidu
map
Baidu
map
Baidu
map