Clin Microbiol Infect：无创通气患者使用喷雾抗生素治疗临床研究推荐

2017-04-19 MedSci MedSci原创

喷雾抗生素在无创性机械通气患者中的使用临床上并不少见，但是其有效性及安全性缺少有效的临床证据。Clin Microbiol Infect杂志中一篇文章对这一临床应用进行了研究报道。由于抗生素的滥用，抗生素耐药性的增加以及新药的缺乏，使得我们急需一种能加强抗生素有效性的方法。因此，作为一种潜在的优化治疗方式的喷雾抗生素，尤其是其在治疗多耐药(MDR)病原体感染患者中的潜在价值，引起了人们极大的兴趣。

喷雾抗生素在无创性机械通气患者中的使用临床上并不少见，但是其有效性及安全性缺少有效的临床证据。Clin Microbiol Infect杂志中一篇文章对这一临床应用进行了研究报道。

由于抗生素的滥用，抗生素耐药性的增加以及新药的缺乏，使得我们急需一种能加强抗生素有效性的方法。因此，作为一种潜在的优化治疗方式的喷雾抗生素，尤其是其在治疗多耐药(MDR)病原体感染患者中的潜在价值，引起了人们极大的兴趣。

基于推荐评估的等级、发展及评估的（GRADE）方法论，针对喷雾抗生素在无创机械通气的成年患者中的使用，通过对现存文献进行回顾和进行了Meta分析后，欧洲临床微生物学和传染病学会的建议书提出了一些建议。

一些文章不推荐喷雾抗生素在临床的使用，主要是考虑到其疗效不显着及明显副作用，但是这些结论缺乏有力的研究证据。临床实践急需高质量的证据来支撑。专家组急需进行一项临床随机试验，使用喷雾抗生素来代替传统方法，治疗多耐药病原体感染的肺炎。

原始出处：

Rello J， Solé-Lleonart C， Rouby JJ，et al.Use of Nebulized Antimicrobials for the Treatment of Respiratory Infections in Invasively Mechanically Ventilated Adults： A Position Paper from the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect. 2017 Apr 13. pii： S1198-743X(17)30219-7. doi： 10.1016/j.cmi.2017.04.011.

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2017-10-01 12498ebem31暂无昵称

#Biol#

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2017-05-15 sunylz

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2017-10-28 xjy02

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2017-12-07 jiafufeng@yaho

#CRO#

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2017-04-21 ms1260584454294838

#抗生素治疗#

55 0
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2017-04-21 yhy100203

#无创通气#

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