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基于铁氧化物的纳米颗粒，肿瘤特异性释放单线态氧

2017-05-16 X-MOL X-MOL

铁氧化物纳米颗粒肿瘤
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活性氧（ROS）诱导的细胞凋亡已广泛应用于癌症的治疗。尽管光动力治疗（PDT）受益于活性氧生成的空间 - 时间控制，但其对光、光敏剂和氧气的精细匹配需求极大地阻碍了 PDT 作为癌症治疗选择的首选。美国国立卫生研究院的陈小元教授课题组与厦门大学的聂立铭教授课题组合作，开发了一种基于铁氧化物的肿瘤特异性酸性 pH 可控释放单线态氧的纳米颗粒。酸性条件下，铁氧化物颗粒（IO-LAHP）释放的铁



活性氧（ROS）诱导的细胞凋亡已广泛应用于癌症的治疗。尽管光动力治疗（PDT）受益于活性氧生成的空间 - 时间控制，但其对光、光敏剂和氧气的精细匹配需求极大地阻碍了 PDT 作为癌症治疗选择的首选。

美国国立卫生研究院的陈小元教授课题组与厦门大学的聂立铭教授课题组合作，开发了一种基于铁氧化物的肿瘤特异性酸性 pH 可控释放单线态氧的纳米颗粒。酸性条件下，铁氧化物颗粒（IO-LAHP）释放的铁（II）离子与纳米颗粒表面的亚油酸氢过氧化物（LAHP）之间发生类 Fenton 反应，实现了基于 ROS 介导机制的肿瘤特异性治疗。体外细胞实验表明 IO-LAHP NPs 可有效地提高肿瘤细胞内的 ROS 水平，进而诱发凋亡性癌细胞；体内小鼠肿瘤模型实验进一步证实了该纳米颗粒对小鼠肿瘤的生长有明显的抑制作用。

这项研究工作提出了一种基于生物化学反应药物实现可控特异性肿瘤治疗的新方法。该结果发表于 Angewandte Chemie International Edition 上。该工作由陈小元教授课题组的周子健博士等人完成，聂立铭和陈小元教授是本研究的通讯作者，研究工作得到了国家自然科学基金委、国家科技部 863 课题以及福建省自然科学基金和厦门大学校长基金等项目的支持。(生物谷 Bioon.com)

原文出处：

Zijian Zhou et al.Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therap，Angewandte Chemie International Edition(2017).DOI： 10.1002/anie.201701181

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    2017-07-30 saikp

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    2017-05-18 ms3117646317107274

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