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NEJM:新型银屑病药物的治疗效率优于当前标准疗法

2015-07-10 佚名 生物谷

近日,一项发表于国际杂志New England Journal of Medicine上的研究论文中,来自美国西北大学的研究人员通过进行一项II期临床试验,结果表明,一种名为guselkumab的银屑病药物或可优于当前的标准疗法用于治疗慢性的皮肤疾病,文章中研究者对比了guselkumab和阿达木单抗的疗效,后者药物是一种常用于治疗银屑病的药物。研究者Kenneth Gordon博士表示,我们的研

近日,一项发表于国际杂志New England Journal of Medicine上的研究论文中,来自美国西北大学的研究人员通过进行一项II期临床试验,结果表明,一种名为guselkumab的银屑病药物或可优于当前的标准疗法用于治疗慢性的皮肤疾病,文章中研究者对比了guselkumab和阿达木单抗的疗效,后者药物是一种常用于治疗银屑病的药物。

研究者Kenneth Gordon博士表示,我们的研究旨在寻找一系列新型药物来帮助患者抵御慢性皮肤疾病的发展;银屑病是一种免疫介导的疾病,其主要引发患者皮肤瘙痒、干燥以及出现红疹等,同时还会增加患者患抑郁症、心脏病及糖尿病等疾病的风险。目前银屑病在全球几乎影响着3%个体的健康,在所有病人中大约有一半银屑病患者都没有得到合适的治疗。

对于患者而言,该病将一直伴随他们存在,在本文进行的多中心联合研究中,研究人员对293名患中度至重度的银屑病患者进行研究,随机让患者接受两种药物中(药物guselkumab和阿达木单抗)的一种或安慰剂进行长达52周的治疗。在治疗16周和40周时,研究者对药物治疗的效率进行了级别的测量,即0-5,结果显示,相比阿达木单抗治疗组和安慰剂服用组患者而言,服用药物guselkumab的治疗组患者中大部分个体的得分都为0(银屑病完全清除)或1(轻度银屑病),在治疗40周时,81%的每天服用200mg剂量guselkumab的患者的得分为0或1,而服用阿达木单抗的患者中仅有49%的患者可以达到这样的得分。

研究者表示,这种新型药物是通过阻断参与银屑病发生的关键蛋白白介素23的功能来发挥作用的,Gordon表示,基于临床和前期基础研究,后期我们将改变对银屑病发病机制以及疗法的认识,本文研究或为我们提出了一种治疗银屑病的新见解,目前正在进行的III期临床试验中我们将会检测药物guselkumab的安全性以及有效性。

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    2015-12-28 1de1e491m94(暂无匿称)

    真心希望可以让银屑病患者能过快乐的面对人生和家人

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=49917, encodeId=1c0a4991eb3, content=真心希望可以让银屑病患者能过快乐的面对人生和家人, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88391674988, createdName=1de1e491m94(暂无匿称), createdTime=Mon Dec 28 13:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061217, encodeId=f266206121e34, content=<a href='/topic/show?id=f29e6193947' target=_blank style='color:#2F92EE;'>#标准疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61939, encryptionId=f29e6193947, topicName=标准疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3679417, createdName=feather78, createdTime=Sun Jan 24 18:49:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32454, encodeId=f1e93245463, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:39:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32377, encodeId=7045323e7ac, content=希望给银屑病带来新的希望!, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Jul 11 20:32:00 CST 2015, time=2015-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32248, encodeId=6b91322488c, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Fri Jul 10 14:34:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32237, encodeId=238c3223e91, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Fri Jul 10 14:23:00 CST 2015, time=2015-07-10, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=49917, encodeId=1c0a4991eb3, content=真心希望可以让银屑病患者能过快乐的面对人生和家人, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88391674988, createdName=1de1e491m94(暂无匿称), createdTime=Mon Dec 28 13:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061217, encodeId=f266206121e34, content=<a href='/topic/show?id=f29e6193947' target=_blank style='color:#2F92EE;'>#标准疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61939, encryptionId=f29e6193947, topicName=标准疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3679417, createdName=feather78, createdTime=Sun Jan 24 18:49:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32454, encodeId=f1e93245463, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:39:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32377, encodeId=7045323e7ac, content=希望给银屑病带来新的希望!, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Jul 11 20:32:00 CST 2015, time=2015-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32248, encodeId=6b91322488c, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Fri Jul 10 14:34:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32237, encodeId=238c3223e91, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Fri Jul 10 14:23:00 CST 2015, time=2015-07-10, status=1, ipAttribution=)]
    2015-07-12 huaxipanxing

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  4. [GetPortalCommentsPageByObjectIdResponse(id=49917, encodeId=1c0a4991eb3, content=真心希望可以让银屑病患者能过快乐的面对人生和家人, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88391674988, createdName=1de1e491m94(暂无匿称), createdTime=Mon Dec 28 13:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061217, encodeId=f266206121e34, content=<a href='/topic/show?id=f29e6193947' target=_blank style='color:#2F92EE;'>#标准疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61939, encryptionId=f29e6193947, topicName=标准疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3679417, createdName=feather78, createdTime=Sun Jan 24 18:49:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32454, encodeId=f1e93245463, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:39:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32377, encodeId=7045323e7ac, content=希望给银屑病带来新的希望!, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Jul 11 20:32:00 CST 2015, time=2015-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32248, encodeId=6b91322488c, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Fri Jul 10 14:34:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32237, encodeId=238c3223e91, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Fri Jul 10 14:23:00 CST 2015, time=2015-07-10, status=1, ipAttribution=)]
    2015-07-11 Jianghuiqin

    希望给银屑病带来新的希望!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=49917, encodeId=1c0a4991eb3, content=真心希望可以让银屑病患者能过快乐的面对人生和家人, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=88391674988, createdName=1de1e491m94(暂无匿称), createdTime=Mon Dec 28 13:04:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061217, encodeId=f266206121e34, content=<a href='/topic/show?id=f29e6193947' target=_blank style='color:#2F92EE;'>#标准疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61939, encryptionId=f29e6193947, topicName=标准疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3679417, createdName=feather78, createdTime=Sun Jan 24 18:49:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32454, encodeId=f1e93245463, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:39:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32377, encodeId=7045323e7ac, content=希望给银屑病带来新的希望!, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Jul 11 20:32:00 CST 2015, time=2015-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32248, encodeId=6b91322488c, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Fri Jul 10 14:34:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32237, encodeId=238c3223e91, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Fri Jul 10 14:23:00 CST 2015, time=2015-07-10, status=1, ipAttribution=)]
    2015-07-10 cmn

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    2015-07-10 owlhealth

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