Baidu
map

SCI REP:多囊卵巢综合征中维生素D与肾上腺代谢和炎症标志物的关系

2019-03-09 不详 MedSci原创

维生素D缺乏与多囊卵巢综合征(PCOS)的代谢改变有关。同样,肾上腺轴的过度活化也可以与PCOS发展相关联。因此,本项研究的目的是建立维生素D和肾上腺参数与PCOS中代谢改变和炎症标志物之间的关系。

背景及目的:
维生素D缺乏与多囊卵巢综合征(PCOS)的代谢改变有关。同样,肾上腺轴的过度活化也可以与PCOS发展相关联。因此,本项研究的目的是建立维生素D和肾上腺参数与PCOS中代谢改变和炎症标志物之间的关系。

方法:
研究人员招募了73名PCOS患者和33名健康对照组患者,采用血清检验25-羟基维生素D(25-OH-D),生物可利用的睾酮(TT和bioT),雄烯二酮(A4),SHBG,皮质醇,胰岛素和C-反应蛋白(hs-CRP)的含量。

结果:
除SHBG和25-OH-D较低外,PCOS患者所有参数均高于对照组。二元回归分析显示TT,bioT,胰岛素与体重指数和腰围无关,但SHBG,hs-CRP,LAP和25-OH-D与体重和脂肪分布有关。二元logistic回归分析显示皮质醇和25-OH-D可能与PCOS发展有关。LAP与胰岛素,HOMA和hs-CRP之间的相关性证实它是代谢并发症的良好指标。

结论
本项研究结果表明,多囊卵巢综合征中维生素D的缺乏与PCOS患者的症状严重程度有关,且SHBG,hs-CRP,LAP和25-OH-D与体重和脂肪分布有关。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1764835, encodeId=fe3d1e6483584, content=<a href='/topic/show?id=cb0d6e045dc' target=_blank style='color:#2F92EE;'>#炎症标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67045, encryptionId=cb0d6e045dc, topicName=炎症标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b9437807464, createdName=ms7405317358118777, createdTime=Mon Jan 13 13:19:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718410, encodeId=b07d1e18410b1, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Sat Nov 16 02:19:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895168, encodeId=f7f4189516883, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Sep 03 17:19:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841370, encodeId=ca7918413e011, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Oct 05 00:19:00 CST 2019, time=2019-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431459, encodeId=56ea143145992, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 11 07:19:00 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1764835, encodeId=fe3d1e6483584, content=<a href='/topic/show?id=cb0d6e045dc' target=_blank style='color:#2F92EE;'>#炎症标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67045, encryptionId=cb0d6e045dc, topicName=炎症标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b9437807464, createdName=ms7405317358118777, createdTime=Mon Jan 13 13:19:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718410, encodeId=b07d1e18410b1, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Sat Nov 16 02:19:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895168, encodeId=f7f4189516883, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Sep 03 17:19:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841370, encodeId=ca7918413e011, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Oct 05 00:19:00 CST 2019, time=2019-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431459, encodeId=56ea143145992, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 11 07:19:00 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1764835, encodeId=fe3d1e6483584, content=<a href='/topic/show?id=cb0d6e045dc' target=_blank style='color:#2F92EE;'>#炎症标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67045, encryptionId=cb0d6e045dc, topicName=炎症标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b9437807464, createdName=ms7405317358118777, createdTime=Mon Jan 13 13:19:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718410, encodeId=b07d1e18410b1, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Sat Nov 16 02:19:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895168, encodeId=f7f4189516883, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Sep 03 17:19:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841370, encodeId=ca7918413e011, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Oct 05 00:19:00 CST 2019, time=2019-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431459, encodeId=56ea143145992, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 11 07:19:00 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1764835, encodeId=fe3d1e6483584, content=<a href='/topic/show?id=cb0d6e045dc' target=_blank style='color:#2F92EE;'>#炎症标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67045, encryptionId=cb0d6e045dc, topicName=炎症标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b9437807464, createdName=ms7405317358118777, createdTime=Mon Jan 13 13:19:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718410, encodeId=b07d1e18410b1, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Sat Nov 16 02:19:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895168, encodeId=f7f4189516883, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Sep 03 17:19:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841370, encodeId=ca7918413e011, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Oct 05 00:19:00 CST 2019, time=2019-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431459, encodeId=56ea143145992, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 11 07:19:00 CST 2019, time=2019-03-11, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1764835, encodeId=fe3d1e6483584, content=<a href='/topic/show?id=cb0d6e045dc' target=_blank style='color:#2F92EE;'>#炎症标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67045, encryptionId=cb0d6e045dc, topicName=炎症标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b9437807464, createdName=ms7405317358118777, createdTime=Mon Jan 13 13:19:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718410, encodeId=b07d1e18410b1, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Sat Nov 16 02:19:00 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895168, encodeId=f7f4189516883, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Tue Sep 03 17:19:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841370, encodeId=ca7918413e011, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Oct 05 00:19:00 CST 2019, time=2019-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431459, encodeId=56ea143145992, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 11 07:19:00 CST 2019, time=2019-03-11, status=1, ipAttribution=)]

相关资讯

BMC Gastroenterology: 维生素D对高脂饮食和棕榈酸诱导的小鼠肠神经元损失具有神经保护作用

目前,维生素D在肥胖和糖尿病中的作用存在争议。肥胖和/或糖尿病患者的游离脂肪酸水平升高,且对胃肠道症状的易感性增加。肠神经系统在调节胃肠活动中起关键作用,并且已经显示高脂肪饮食(HFD)导致回肠和结肠中肠神经元的损失。因此,本项研究旨在探究维生素D对体内和体外HFD-和棕榈酸诱导的肠神经元损失的影响。

JCC: 孕妇炎症性肠病患者的维生素D不足的风险会增加:横断面研究

维生素D不足在患有炎性肠病[IBD]的个体以及孕妇中普遍存在, 然而,IBD孕妇中维生素D不足的患病率尚不清楚。本研究评估了IBD孕妇中维生素D不足的患病率。

BBC:一个来自20年慢性背痛患者的故事

很多背痛都是自愈性的,然而英国医生 Rangan Chatterjee却遇到了一个遭受20多年慢性背痛的患者,背痛给这位患者的健康和生活都带来了严重的影响。他时常因为背痛而不能工作,甚至严重时还需要住院治疗,这使他的家庭财务状况不容乐观。

Leukemia:维生素C能诱导IDH1突变的急性髓系白血病的表观遗传修饰

科学家在白血病模型中设计了一个研究vitamin C在驱动分化的转录因子结合位点诱导表观遗传修饰的研究模型,从而揭示了vitamin C 的表观修饰作用。

Baidu
map
Baidu
map
Baidu
map