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Semin Arthritis Rheu:吸烟是巨细胞动脉炎的危险因素

2018-07-13 xiangting MedSci原创

这项研究表明,与非吸烟者相比,目前吸烟和既往吸烟者的GCA风险显著升高。

这项研究旨在调查吸烟与巨细胞动脉炎(GCA)之间的关联。

这是一项系统评价和meta分析,纳入了对GCA患者和非GCA对照吸烟史和GCA进行比较的观察性研究,这些研究必须有比较的绝对数值和/或统计学的95%置信区间。根据PRISMA指南对研究进行了审查。从单个研究中提取点估计值和标准误,并通过DerSimonian和Laird的通用逆方差方法进行组合。进行随机效应荟萃分析。使用Cochran Q检验评估统计异质性,该检验用I2统计量补充。

最初检索发现了3312篇文章。其中,确定了13项具有独特队列的研究(8项前瞻性研究和5项回顾性病例对照研究),并纳入初步分析(既往吸烟vs.从不吸烟)。GCA队列中的患者更可能有吸烟史,优势比为1.19(95%CI,1.01-1.39)。存在相当大的异质性(I2=85%)。其中5项研究包括当前吸烟状况的信息。另一项仅报告了目前吸烟状况的研究也被纳入。GCA队列显示与当前吸烟有关,优势比为1.18(95%CI,1.01-1.38)。

这项研究表明,与非吸烟者相比,目前吸烟和既往吸烟者的GCA风险显著升高。

原始出处:
David N.Brennan, et al. Smoking as a Risk Factor for Giant Cell Arteritis: A Systematic Review and Meta-Analysis. Semin Arthritis Rheu. 11 July 2018.

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    2018-12-25 xsm927
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    2018-07-19 1e145228m78(暂无匿称)

    学习了谢谢作者分享

    0

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    2018-07-15 zhaojie88
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    2018-07-15 wwzzly
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    2018-07-13 三生有幸9135

    学习一下

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