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Stroke:无症状性颈动脉闭塞患者,死亡率增加

2016-06-30 phylis 译 MedSci原创

目的:本系统评价的目的是量化无症状的颈动脉闭塞(ACAO)发生同侧卒中的风险。方法:通过检索MEDLINE,EMBASE以及研究书目,识别报告ACAO发生同侧卒中风险的研究。应用随机效应模型,综合研究评估,应用I(2)统计对研究异质性进行量化。主要预后为同侧卒中的年发生率。结果:共识别出13项研究,包括718例ACAO的患者,随访时间的中位数为2.8年。同侧卒中的年发生率为1.3%(95% CI,

目的:本系统评价的目的是量化无症状的颈动脉闭塞(ACAO)发生同侧卒中的风险。

方法:通过检索MEDLINE,EMBASE以及研究书目,识别报告ACAO发生同侧卒中风险的研究。应用随机效应模型,综合研究评估,应用I(2)统计对研究异质性进行量化。主要预后为同侧卒中的年发生率。

结果:共识别出13项研究,包括718例ACAO的患者,随访时间的中位数为2.8年。同侧卒中的年发生率为1.3%(95% CI,0.4-2.1;I(2)= 53%)。同侧短暂性脑缺血发作的年增长率为1%(95%CI,0.3-1.8;I(2)= 40%)。年死亡率明显升高7.7%(95%CI,4.3-11.2;I(2)= 83%)。校正主要预后可能的发表偏倚,显示同侧卒中的风险较低(每年0.3%;95%CI,- 0.4至1.1)。

结论:ACAO患者卒中发生率相对较低,但患者死亡率增高。这表明,需要强化治疗颈动脉闭塞患者。

原始出处:

Hackam DG. Prognosis of Asymptomatic Carotid Artery Occlusion: Systematic Review and Meta-Analysis. Stroke. 2016 May


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    2016-10-11 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

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