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BJC:与女性结直肠腺癌相关的生育因素研究

2016-10-07 Mechront 译 MedSci原创

目前关于内源性性激素对结直肠肿瘤发生的影响是相互矛盾的。本项以人口为基础的研究,纳入了来自四个北欧国家的数据,以评估女性生育史对结直肠腺癌风险的影响。 我们进行了一项以人群为基础的病例对照研究,这项研究包括在1967–2013年、在丹麦、芬兰、挪威和瑞典诊断为结直肠腺癌的女性患者,按1:10匹配对照组。 总的来说,共有22 185例结直肠腺癌患者和220 246例对照组。 数据显

目前关于内源性性激素对结直肠肿瘤发生的影响是相互矛盾的。本项以人口为基础的研究,纳入了来自四个北欧国家的数据,以评估女性生育史对结直肠腺癌风险的影响。

我们进行了一项以人群为基础的病例对照研究,这项研究包括在1967–2013年、在丹麦、芬兰、挪威和瑞典诊断为结直肠腺癌的女性患者,按1:10匹配对照组。

总的来说,共有22 185例结直肠腺癌患者和220 246例对照组。

数据显示,以下因素与结直肠腺癌无关:产次、首次分娩年龄、末次分娩年龄、首次分娩到末次分娩的间隔时间。

不同部位结直肠腺癌(结肠近端和远端、直肠)风险评估接近一致。

此外,绝经状态、产次、母亲出生年份也与结直肠腺癌无关。

本项大型的北欧人群的研究表明,没有发现与女性结直肠腺癌相关的生育因素。

原始出处:


Tone Bjørge,et al.Reproductive history and risk of colorectal adenocarcinoma in parous women: a Nordic population-based case–control study.British Journal of Cancer advance online publication 4 October 2016

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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=145321, encodeId=768714532185, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Oct 11 20:14:24 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=143069, encodeId=199c14306916, content=文章很好,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Oct 10 10:54:00 CST 2016, time=2016-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452839, encodeId=102914528391f, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 09 05:47:00 CST 2016, time=2016-10-09, status=1, ipAttribution=)]
    2016-10-10 1e10c84am36(暂无匿称)

    文章很好,继续关注

    0

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