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JAMA Psychiatry:自身免疫病与严重感染者易发心境障碍

2013-06-27 姜珊 编译 中国医学论坛报

丹麦和美国联合研究表明,自身免疫病和感染是心境障碍的危险因素。论文6月12日在线发表于《美国医学会杂志·精神病学》(JAMA Psychiatry)。 研究纳入1945至1996年间出生者356万人,自1977年1月1日随访至2010年12月31日。主要终点为首发心境障碍风险。结果为,共91637例发生心境障碍。自身免疫病和感染住院史分别使随后心境障碍诊断的风险增加45%[发病

丹麦和美国联合研究表明,自身免疫病和感染是心境障碍的危险因素。论文6月12日在线发表于《美国医学会杂志·精神病学》(JAMA Psychiatry)。

研究纳入1945至1996年间出生者356万人,自1977年1月1日随访至2010年12月31日。主要终点为首发心境障碍风险。结果为,共91637例发生心境障碍。自身免疫病和感染住院史分别使随后心境障碍诊断的风险增加45%[发病率比(IRR)=1.45]和62%(IRR=1.62)。两个危险因素协同作用,进一步增加随后心境障碍风险(IRR=2.35)。确诊心境障碍者,约1/3曾因感染于医院就诊,5%有自身免疫病史。



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