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J Rheumatol:银屑病关节炎患者的内分泌并发症

2017-04-24 xiangting MedSci原创

PsA与甲低、骨质疏松症、DM和库兴病等并发症出现频率高有关。

近日风湿领域权威杂志Journal of Rheumatolgy上发表了一篇文章,旨在研究银屑病关节炎患者的内分泌并发症(PsA),这是一项基于人群的病例对照研究。

研究人员利用以色列Clalit Health Services数据库对2002年至2014年间的病例进行回顾性的横断面研究。查找PsA病例并和年龄、性别相匹配的健康对照进行比较。分析以下情况的发病率:甲低/甲状腺功能亢进、甲状旁腺功能低下/甲状旁腺功能亢进、高催乳素血症,库兴病,Addison病,尿崩症,糖尿病(DM),垂体腺瘤,肢端肥大症和骨质疏松症。应用描述性统计。通过单变量和多变量分析来分析PsA与内分泌并发症之间的关联。

研究包括3161例PsA患者,53.4%为女性,平均年龄为58.4±15.4岁,对照组为31,610例。比较分析显示甲状腺功能减退(12.7%vs 8.6%,P<0.0001),库兴病 (0.3%vs 0.1%,P<0.0001),骨质疏松症(13.2%vs 9.1%,P<0.0001)和DM(27.9%vs 20.7%,P<0.0001)并发症出现频率PsA组高于对照组。经多元回归分析,发现以下疾病在PsA组中出现频率更高:甲状腺功能减退(OR 1.61,95%CI 1.47-1.81),DM(OR 1.35,95%CI 1.18-1.42),库兴病(OR 3.96,95%CI 1.67-9.43)和骨质疏松症(OR 1.56,95%CI 1.37-1.78)。

由此可见PsA与甲低、骨质疏松症、DM和库兴病等并发症出现频率高有关。意识到这些合并症有助于医生为PsA患者提供最佳的医疗策略。

原始出处:


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    2018-02-01 gwc392
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    2017-04-26 lmm397
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    2017-04-25 hippoandxym1727

    学习了

    0

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    2017-04-24 lovetcm

    可能背后都是免疫问题,当然内分泌系统本身也会影响免疫系统

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1682299, encodeId=f5611682299c8, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Thu Feb 01 22:55:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757781, encodeId=3da01e5778156, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Mon Feb 26 00:55:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815014, encodeId=5b0e1815014a5, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Mon Oct 16 23:55:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265391, encodeId=6ea6126539158, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Apr 26 06:55:00 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190346, encodeId=5d2919034637, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRryoiaM3hYcC93J7aWyPQ4d7aKyTcCfpOkf1Le6znZg6FNLRvoNRXwCeYVDCcNUA1odC3oD8SlzQ8/0, createdBy=30281833508, createdName=hippoandxym1727, createdTime=Tue Apr 25 06:22:13 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190260, encodeId=ce1c1902600b, content=可能背后都是免疫问题,当然内分泌系统本身也会影响免疫系统, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Mon Apr 24 22:03:39 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190233, encodeId=47c4190233a8, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon Apr 24 19:58:30 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190209, encodeId=9259190209fc, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Mon Apr 24 17:29:21 CST 2017, time=2017-04-24, status=1, ipAttribution=)]
    2017-04-24 dhzzm

    学习了分享了

    0

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    2017-04-24 shaosai

    好好学习,涨知识

    0

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