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Clin Transl Allergy:鼻炎患者中的过敏性多重病症研究

2020-03-23 AlexYang MedSci原创

鼻炎是一种常见的疾病。许多鼻炎患者同时具有过敏性多重病症,比如哮喘和湿疹。最近,有研究人员对只患有鼻炎的患者和患有鼻炎,哮喘和/或湿疹的患者进行了比较,涉及了免疫球蛋白E(lgE)敏感、炎症标记、家族

鼻炎是一种常见的疾病。许多鼻炎患者同时具有过敏性多重病症,比如哮喘和湿疹。最近,有研究人员对只患有鼻炎的患者和患有鼻炎,哮喘和/或湿疹的患者进行了比较,涉及了免疫球蛋白E(lgE)敏感、炎症标记、家族历史、肺功能和身体质量指数(BMI)。

研究总共包括了216名成年鼻炎患者,并进行了多重组分过敏原分析(103中过敏原组分)。研究发现,216名鼻炎患者中,89名具有哮喘和/或湿疹。同时患有鼻炎和哮喘/湿疹的参与者更可能是lgE敏感(3.44, OR: 95% CI 1.62-7.30, 调整性别、年龄、母亲过敏、总lgE和肺活量(FEV1)后)。在调整性别、年龄、母亲过敏、总lgE和肺活量(FEV1)后,lgE阳性组分数与过敏性多重病症独立相关(1.11, OR: 95% Cl 1.01-1.21)。当分析了不同类型的敏感后,与过敏性多重病症相关性最强烈的存在于对常年和季节性过敏原均lgE敏感的参与者中(4.50, OR: 95% CI 1.61-12.5)。另外,母体过敏(2.75, OR: 95% CI 1.15-4.46)、高总lgE(2.38, OR: 95% CI 1.21-4.67)和更低的FEV1(0.73, OR: 95% CI 0.58-0.93)均与多重病症独立相关,而没有发现与其他炎症标记的相关性。

最后,研究人员指出,对常年性和季节性过敏原的lgE多重致敏和lgE水平是鼻炎患者中过敏性多重病症的主要决定因素。表明了靶向lgE敏感的治疗对减少发展为过敏性多重病症很有价值。

原始出处:

Blondal V, Sundbom F, Borres MP et al. Study of atopic multimorbidity in subjects with rhinitis using multiplex allergen component analysis. Clin Transl Allergy. 21 Feb 2020.

 

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    2020-07-28 bsmagic9140
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    2020-03-25 膀胱癌

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