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Sci Transl Med:肾病患者不用再发愁,人体干细胞注入法成功治愈肾病小鼠

2017-10-01 Heather_z727 译 Medicalxpress

近日,发表在《科学转化医学》杂志上的研究报告记录了来自日本京都大学的医学研究,通过对缺血性肾病小鼠注射人类干细胞,成功治愈了小鼠的肾病

近日,发表在《科学转化医学》杂志上的研究报告记录了来自日本京都大学的医学研究,通过对缺血性肾病小鼠注射人类干细胞,成功治愈了小鼠的肾病。

慢性肾脏疾病是一种严重的疾病,由于身体处理能力的降低,最终会导致患者肾功能衰竭,这就使得患者需要进行透析或肾移植。缺血性肾病就是其中一种,目前治疗的方法就是注射促红细胞生成素,但是由于高昂的价格以及治疗带来的副作用,对许多人来说都是不切实际的。在这个新的研究中,研究人员发现了一种潜在的新方法,通过注射自身干细胞来解决这一问题。

在实验过程中,研究人员收集了人类脐带血干细胞,然后改变他们的生长因子多能干细胞成长为成熟细胞,具有产生促红细胞生成素的能力,之后团队将细胞注入患有慢性肾病的小鼠体内。

研究小组报告说,通过四周的治疗,所有的老鼠的EPO水平恢复到正常范围内。在研究报告中,小组负责人指出,这一发现意味着人类干细胞可以治愈这种疾病。

当然,目前还不清楚对于人类患者的作用,但是基于小鼠实验的成功,研究人员信心百倍,接下来,他们将开始进行大规模的人体实验,以确定新方法的安全有效性。一旦试验成功,人类再也不要担心慢性肾脏问题引起的致命健康隐患。

原始出处:Hitomi H, Kasahara T, Katagiri N, et al. Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice. Sci Transl Med. 2017 Sep 27.

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    2017-10-27 bsmagic9140
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    2017-10-02 1ddf0692m34(暂无匿称)

    学习了涨知识

    0

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    2017-10-01 林3301

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