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BMC Gastroenterology:改善睡眠障碍对功能性消化不良患者症状的改善具有重要意义

2021-02-26 MedSci原创 MedSci原创

众所周知,许多患者具有功能性胃肠(GI)紊乱的患者都存在睡眠障碍,功能性消化不良(FD)也常与睡眠障碍相伴发生。

      众所周知,许多患者具有功能性胃肠(GI)紊乱的患者都存在睡眠障碍,功能性消化不良(FD)也常与睡眠障碍相伴发生,然而,大多数研究仅指出了胃肠道症状与睡眠障碍之间的关联,很少有关注如何通过改善睡眠障碍来改善胃肠道症状的研究。有专家认为睡眠障碍可能导致FD患者的内脏超敏反应由此导致胃肠道症状的出现。因此,本项研究的目的是探究睡眠药物对FD患者胃肠道症状的影响,并阐明FD与睡眠障碍之间的关系。

 

 

      研究人员在2018年12月至2019年7月间招募了20名有睡眠障碍的FD患者。所有患者服用了帮助睡眠的药物长达4周,并在服用助眠剂之前和之后填写了问卷。使用匹兹堡睡眠质量指数(PSQI),爱德华嗜睡量表(ESS)和雅典失眠量表(AIS)用于评估其睡眠障碍的严重程度。改良的胃食管反流病症状频率量表(mFSSG),胃肠道症状评定量表(GSRS)和便秘患者生活质量评估(JPAC-QOL)量表用于评估GI症状的严重程度。简短的36项健康调查(SF-36)用于评估QOL。最后比较了问卷前后的得分差异以评估助眠药物价值。

 

 

      在20名入组患者中,有16名完成了研究方案。研究中总共使用了三种助眠药物。问卷的每个中位数总分(分别为睡前/睡后药物)如下:PSQI,10.0  VS 8.5;ESS,12.5  VS 5.0;AIS,10.0 VS 4.0;mFSSG,21.0 VS 16.0;GSRS,44.0 VS 31.0(GSRS中的疼痛,11.0 VS 5.0);JPAC-QOL,26.0 VS 15.5;SF-36,63.9 VS 71.9。所有这些结果表明睡前和睡后药物之间存在统计学上的显着差异(p  <0.05),由此说明使用助眠药物以后所有指标均获得一定程度的改善,助眠药物可以通过改善睡眠质量来改善胃肠道症状。

 

 

      作者最后说道:通过服用睡眠辅助药物可以改善睡眠障碍,并进一步改善FD患者的胃肠道症状,焦虑症和生活质量。这些影响可能与疼痛缓解有关,但是需要进一步的研究进行证实。

 

 

 

原始出处:

Fumihiko Nakamura. Et al. Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia. BMC Gastroenterology.2021.

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    2021-10-09 许安
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time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=943840, encodeId=60af94384040, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210225/0f23bbdc8e024afe910167410a35f46d/44bc25c2b2564192ad1d4c38de8083fa.jpg, createdBy=f02b5455235, createdName=zsj2002534, createdTime=Fri Feb 26 22:39:38 CST 2021, time=2021-02-26, status=1, ipAttribution=)]
    2021-03-04 栖止木

    感觉睡眠改善是个中间环节,睡眠质量变好,人的精神状态和情绪变好,更有信心胃肠道症状也会治好。

    0

  8. 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  9. 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time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=943840, encodeId=60af94384040, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210225/0f23bbdc8e024afe910167410a35f46d/44bc25c2b2564192ad1d4c38de8083fa.jpg, createdBy=f02b5455235, createdName=zsj2002534, createdTime=Fri Feb 26 22:39:38 CST 2021, time=2021-02-26, status=1, ipAttribution=)]
    2021-02-27 学医无涯

    改善睡眠,意义重大!

    0

  10. 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time=2021-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=943840, encodeId=60af94384040, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210225/0f23bbdc8e024afe910167410a35f46d/44bc25c2b2564192ad1d4c38de8083fa.jpg, createdBy=f02b5455235, createdName=zsj2002534, createdTime=Fri Feb 26 22:39:38 CST 2021, time=2021-02-26, status=1, ipAttribution=)]
    2021-02-26 zsj2002534

    不错

    0

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Am J Gastroenterol:ACG / CAG联合消化不良诊断和治疗指南

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他是慢性胃炎还是功能性消化不良?

张先生,43岁。患有慢性胃病多年,近几年来常有上腹饱胀、嗳气、打嗝、烧心、反酸等症状,少量进食就有上腹饱胀感,时好时坏,多次到医院B超检查肝胆胰脾未发现异常,肝肾功能正常,多次胃镜检查诊断为“慢性浅表性胃炎’’(现在称为:慢性非萎缩性胃炎)。也无糖尿病、慢性肝炎等病史。

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