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ESMO世界胃肠癌大会：murlentamab的II期临床研究结果

2019-07-07 Allan MedSci原创

murlentamabESMO
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GamaMabs是一家临床阶段生物技术公司，专注于开发抗AMHRII的抗体药物，近日宣布，将在ESMO世界胃肠癌大会上公布murlentamab治疗转移性结直肠癌（mCRC）II期临床数据。

GamaMabs是一家临床阶段生物技术公司，专注于开发抗AMHRII的抗体药物，近日宣布，将在ESMO世界胃肠癌大会上公布murlentamab治疗转移性结直肠癌（mCRC）II期临床数据。

结果显示，murlentamab与trifluridine/tipiracil联用时，PFS率比预期更长（在4个月和6个月时分别为40％和31％）。更令人惊喜的是，在AMHRII阳性肿瘤细胞超过20％的患者中，4个月和6个月时的PFS率分别为83％和75％。murlentamab单药治疗和murlentamab联合trifluridine/tipiracil治疗时，肿瘤生长速率分别下降了1.7倍和3.6倍。


原始出处：

http://www.firstwordpharma.com/node/1651651#axzz5syvQI0kQ

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    2019-11-09 huiwelcome

    #II期临床研究#

    0

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    2020-05-14 1249894fm84暂无昵称

    #研究结果#

    0

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    2019-09-26 snf701207

    #mAb#

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    2020-01-11 医生2402

    #I期临床#

    0

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    2019-10-19 liuhuangbo

    #SMO#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1649991, encodeId=dda91649991da, content=<a href='/topic/show?id=21a496002b' target=_blank style='color:#2F92EE;'>#II期临床研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9600, encryptionId=21a496002b, topicName=II期临床研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=891023951385, createdName=huiwelcome, createdTime=Sat Nov 09 18:28:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739514, encodeId=493c1e39514e2, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Thu May 14 22:28:00 CST 2020, time=2020-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912167, encodeId=2136191216e3d, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Thu Sep 26 10:28:00 CST 2019, time=2019-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652913, encodeId=a3401652913a8, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Sat Jan 11 22:28:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024839, encodeId=2bdc20248399b, content=<a href='/topic/show?id=c27516459de' target=_blank style='color:#2F92EE;'>#SMO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16459, encryptionId=c27516459de, topicName=SMO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6779163, createdName=liuhuangbo, createdTime=Sat Oct 19 15:28:00 CST 2019, time=2019-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280982, encodeId=e46f1280982b4, content=<a href='/topic/show?id=50d6e0215a' target=_blank style='color:#2F92EE;'>#ESMO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7021, encryptionId=50d6e0215a, topicName=ESMO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Tue Jul 09 08:28:00 CST 2019, time=2019-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524717, encodeId=4d8e1524e17a9, content=<a href='/topic/show?id=4ba395994d' target=_blank style='color:#2F92EE;'>#II期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9599, encryptionId=4ba395994d, topicName=II期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=139811614978, createdName=guihongzh, createdTime=Tue Jul 09 08:28:00 CST 2019, time=2019-07-09, status=1, ipAttribution=)]
    2019-07-09 zhang92560

    #ESMO#

    0

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    2019-07-09 guihongzh

    #II期临床#

    0

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