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Sci Rep：调控MiR-449c-5p或可用于治疗钙化性主动脉瓣疾病

2017-09-03 MedSci MedSci原创

钙化性主动脉瓣疾病MiR-449c-5p
关注

钙化性主动脉瓣疾病（CAVD）是最常见的心脏瓣膜疾病，但其作用机制仍不清楚。瓣膜间质细胞（VICS）是主动脉瓣最常见的细胞，且其成骨分化或是CAVD钙化结节形成的原因。新的证据表明，microRNA（miRNA，或MIR）是许多病理过程的重要调节因子，包括成骨分化。本研究旨在探究CAVD发病过程中mir-449c-5p的功能。在这项研究中，研究人员证明了mir-449c-5p 在VICS成骨中的作

钙化性主动脉瓣疾病（CAVD）是最常见的心脏瓣膜疾病，但其作用机制仍不清楚。瓣膜间质细胞（VICS）是主动脉瓣最常见的细胞，且其成骨分化或是CAVD钙化结节形成的原因。

新的证据表明，microRNA（miRNA，或MIR）是许多病理过程的重要调节因子，包括成骨分化。本研究旨在探究CAVD发病过程中mir-449c-5p的功能。

在这项研究中，研究人员证明了mir-449c-5p 在VICS成骨中的作用。MiRNA芯片检测和qRT-PCR结果显示，与非钙化瓣膜相比，钙化主动脉瓣中mir-449c-5p的表达水平显著降低。在体外Mir-449c-5p过表达可抑制VICs成骨分化，而下调mir-449c-5p则会促进VICs成骨分化。

目标预测分析和双荧光素酶报告基因分析证实Smad4是mir-449c-5p的直接靶目标。此外，敲除Smad4可抑制VICS成骨分化，与上调mir-449c-5p的影响相似。此外，动物实验间接证明mir-449c-5p能减轻主动脉瓣钙化。

总之，该研究结果表明，mir-449c-5p或可通过靶向Smad4作为调节VICS成骨分化的一个新的抑制剂。Mir-449c-5p或是CAVD治疗的一个潜在靶点。

原始出处：

Rongjian Xu, Min Zhao, Yun Yang, et al., MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway. Sci Rep. 2017; 7: 8740. Published online 2017 Aug 18. doi: 10.1038/s41598-017-09390-z.

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    2018-01-18 smallant2002

    #miR#

    0

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    2017-09-05 ms3994565386320060

    #主动脉瓣疾病#

    0

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    2017-09-05 circumcision

    #主动脉#

    0

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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dcd2089597, createdName=尉志鹏, createdTime=Mon Sep 04 06:25:18 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
    2017-09-05 医者仁心

    #主动脉瓣#

    0

  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dcd2089597, createdName=尉志鹏, createdTime=Mon Sep 04 06:25:18 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
    2017-09-04 大爰

    学习了谢谢分享!!

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dcd2089597, createdName=尉志鹏, createdTime=Mon Sep 04 06:25:18 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
    2017-09-04 明月清辉

    谢谢分享.学习了

    0

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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 04 07:53:03 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240239, encodeId=6b17240239e5, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Sep 04 07:04:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240225, encodeId=954424022574, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 04 06:46:35 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240220, encodeId=ace6240220de, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Sep 04 06:34:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240215, encodeId=c27124021540, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dcd2089597, createdName=尉志鹏, createdTime=Mon Sep 04 06:25:18 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
    2017-09-04 飛歌

    学习了很有用不错

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 04 07:53:03 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240239, encodeId=6b17240239e5, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Sep 04 07:04:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240225, encodeId=954424022574, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 04 06:46:35 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240220, encodeId=ace6240220de, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Sep 04 06:34:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240215, encodeId=c27124021540, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dcd2089597, createdName=尉志鹏, createdTime=Mon Sep 04 06:25:18 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
    2017-09-04 李东泽

    很好.学习了.很有帮助.

    0

  9. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 04 07:53:03 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240239, encodeId=6b17240239e5, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Sep 04 07:04:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240225, encodeId=954424022574, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 04 06:46:35 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240220, encodeId=ace6240220de, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Sep 04 06:34:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240215, encodeId=c27124021540, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dcd2089597, createdName=尉志鹏, createdTime=Mon Sep 04 06:25:18 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
    2017-09-04 天地飞扬

    谢谢分享!

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Sep 04 07:53:03 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240239, encodeId=6b17240239e5, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Sep 04 07:04:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240225, encodeId=954424022574, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 04 06:46:35 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240220, encodeId=ace6240220de, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Sep 04 06:34:05 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240215, encodeId=c27124021540, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2dcd2089597, createdName=尉志鹏, createdTime=Mon Sep 04 06:25:18 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
    2017-09-04 尉志鹏

    感谢分享

    0

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