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Stroke:脉压对急性缺血性卒中患者主要血管事件的预测价值!

2017-12-06 xing.T MedSci原创

由此可见,在缺血性卒中急性期测得的脉压与主要心血管事件和卒中复发的呈非线性J型关系,脉压可能比其他常用的血压参数具有更好的预测能力。

近日,卒中领域权威杂志Stroke上发表了一篇研究文章,该研究旨在探讨缺血性卒中急性期的脉压(PP)是否可作为未来重大血管事件的预测因子。

研究人员采用多中心前瞻性卒中登记数据库,将在发病后48小时内入院接受治疗的缺血性卒中患者纳入该研究,并分析了发病后3天内血压测量的数据。该研究的主要和次要结局分别为发生卒中复发、心肌梗死、全因死亡复合事件的时间以及卒中复发的时间。

在9840例患者中,4.3%的患者经历了卒中复发,0.2%的患者经历了心肌梗死,1年随访期间死亡的患者占7.3%。在包括线性和二次项脉压的Cox比例风险模型中,脉压与主要(二次项的脉压,P=0.004)和次要(P<0.001)结局之间存在一个非线性的J形关系。脉压和其他血压参数对主要和次要结局的总体影响也有显著意义(P<0.05)。当使用统计量−2对数似然差异来比较血压参数的预测能力,对于主要和次要结局预测,研究人员发现脉压比收缩压(8.49 vs. 5.91;6.32 vs. 4.56)、舒张压(11.42 vs. 11.05;10.07 vs. 4.56)和心房平均压(8.75 vs. 5.91;7.03 vs. 4.56)具有更强的预测能力。

由此可见,在缺血性卒中急性期测得的脉压与主要心血管事件和卒中复发的呈非线性J型关系,脉压可能比其他常用的血压参数具有更好的预测能力。

原始出处:

Keon-Joo Lee,et al. Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Major Vascular Events.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.01958

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    2017-12-06 戒馋,懒,贪

    谢谢分享学习了

    0

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