Baidu
map

Gastroenterol:粪钙卫蛋白监测有助于早期发现克罗恩病术后复发

2015-01-24 lijiasu MedSci原创

近日,澳大利亚圣文森特医院和墨尔本大学等处的研究人员进行了一项前瞻性随机对照试验,发现监测粪钙卫蛋白(Fecal Calprotectin,FC)有助于早期发现克罗恩病术后复发,最新研究成果在线发表于1月22日的Gastroenterology杂志上。

克罗恩病(Crohn’s disease,CD)肠切除术后复发率较高,术后内镜粘膜监测和对症治疗可减少复发几率。近日,澳大利亚圣文森特医院和墨尔本大学等处的研究人员进行了一项前瞻性随机对照试验,发现监测粪钙卫蛋白(Fecal Calprotectin,FC)有助于早期发现克罗恩病术后复发,最新研究成果在线发表于1月22日的Gastroenterology杂志上。该试验共招募到135例患者参与内镜监测疾病复发的评估能力和预防术后克罗恩病复发的阶梯式治疗。研究人员检测了术前和肉眼病灶全切除术后6、12和18个月的患者粪钙卫蛋白水平、血清C反应蛋白和克罗恩病活动指数(CDAI)得分等。90例患者在术后6个月、所有患者在术后18个月还进行了回结肠镜检查。研究结果显示,共检测了135例患者319例样本的粪钙卫蛋白水平。平均粪钙卫蛋白浓度由术前的1347 μg/g下降到术后6个月的166 μg/g,但疾病复发(内镜分析,Rutgeerts得分≥i2)患者较病情缓解者水平明显增高(275 μg/g vs 72 μg/g;P<0.001)。术后6个月和18个月粪钙卫蛋白的组合浓度与克罗恩病复发的

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火,同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火,同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火,同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火,同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
    2015-02-13 许安
  5. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火,同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火,同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=206, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
    2015-01-24 lovetcm

    这个蛋白现在很火,同道借鉴一下

    0

相关资讯

Gut:早发型克罗恩病相关新突变位点被发现

IBD是一组由免疫介导的疾病,其主要特征是慢性复发的肠道炎症和各种各样的肠外表现。IBD肠内外的炎症可能和遗传与环境因素相关,但未能完全解释清楚。随着新一代测序工具的发展,遗传因素的研究成为热点。 来自德国石勒苏益格-荷尔斯泰因州大学医疗中心的Sebastian等进行了一项研究,结果表明CTLA4的变异可能是早发型克罗恩病伴严重自身免疫疾病的孟德尔遗传型的基础,文章发表在2014年11月

Gut:英夫利昔单抗抗体可增加克罗恩病活动性

尽管低的英夫利昔单抗(infliximab,IFX)波谷浓度及其抗体 (ATI) 与克罗恩病患者差的临床效果密切相关,但英夫利昔单抗抗体与患者体内充足的英夫利昔单抗浓度及其与疾病之间的相互关系尚不明确。比利时鲁汶大学和加拿大西安大略大学的研究者进行了一项研究,发现英夫利昔单抗抗体可增加克罗恩病的活动性,相关研究成果在线发表在近期的Gut杂志上。

Liver Int:临床综述:克罗恩病面面观

克罗恩病是一种可累及胃肠道任何部位的慢性、炎性、免疫性疾病,患者涉及所有年龄段,以青年人为高发人群,通常表现为腹泻、腹痛及体重减轻,严重影响患者的工作及生活。多方面的护理,尤其是初级护理,可减少复发,防止长期并发症并提高生活质量。 英国爱丁堡西方总医院遗传和分子医学研究所分子医学中心胃肠病学组的Ian D R Arnott学者及其同事对克罗恩病的诊断、治疗及长期护理等事项进行了归纳总

Lancet:克罗恩病(Crohn)需要积极进行内镜下肠部分切除

大多数患者克罗恩病(Crohn's disease)需要肠切除,但大多数随后将经历疾病复发,需要进一步的手术。这项研究的目的是确定的最优策略,以防止术后复发。最近一项随机对照研究发表在Lancet上。 在这项随机对照试验中,共在澳大利亚和新西兰的17个中心进行患者连续招募。肠切除所有肉眼可见的克罗恩病,用内镜治疗,同时患者接受3个月甲硝唑治疗。患者复发高风险采用巯基嘌呤治疗,如果他们不能耐受硫嘌

Lancet:预防克罗恩病肠切除术后复发的更优化策略

大部分克罗恩病(Crohn's disease)患者需要行肠切除,但之后大多数病人会经历疾病复发和需要进一步的手术治疗。近日,澳大利亚圣文森特医院和墨尔本大学医学院等处的研究者进行了一项随机试验,发现根据临床复发风险及早期结肠镜检查和复发早期加强治疗等情况制定的最优化策略可有效预防疾病术后复发,最新研究成果在线发表于12月23日的The Lancet杂志上。

Baidu
map
Baidu
map
Baidu
map