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Diges Liver Dis:粪便检测结果阳性和粪便血红蛋白浓度与晚期结直肠肿瘤风险增加相关

2019-05-17 不详 MedSci原创

粪便免疫化学试验阳性(FIT)以及粪便血红蛋白浓度都能够反应晚期结直肠肿瘤(ACRN)和结直肠癌(CRC)的病变情况,因此本项研究旨在探究存在阳性结果时结肠镜检查的时间是否应该提前。

背景
粪便免疫化学试验阳性(FIT)以及粪便血红蛋白浓度都能够反应晚期结直肠肿瘤(ACRN)和直肠癌(CRC)的病变情况,因此本项研究旨在探究存在阳性结果时结肠镜检查的时间是否应该提前。

方法
研究人员通过韩国国家癌症筛查计划数据库分析了2362名年龄≥50岁且接受结肠镜检查的患者的记录。

结果
在FIT检测为阳性后,ACRN风险随着结肠镜检查时间的增加而增加(<30天,30-59天,60-149天,150-179天和≥180天分别为17.2%,18.6%,19.1%,21.4%和27.2%; P ?= 0.034),ACRN和CRC风险随着粪便血红蛋白浓度的增加而增加。即使在调整混杂因素后,180天后的随访也往往与较高的ACRN风险相关(HR,1.73; 95%置信区间[CI],0.91-3.27),与后续结肠镜检查相比<30与100-200 ng Hb / mL相比,天数和粪便血红蛋白500-1000和≥1000ngHb / mL与显着更高的ACRN和CRC风险相关。此外,与<180天和<1000 ng Hb / mL(12.45倍; 95%CI,3.73-41.57)的组相比,≥180天和≥1000ngHb / mL的组具有更高的CRC风险。

结论
FIT结果阳性的患者,尤其是粪便血红蛋白水平较高的患者,应及时进行结肠镜检查。

原始出处:

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encryptionId=c3048314322, topicName=肿瘤风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Nov 22 11:11:00 CST 2019, time=2019-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013000, encodeId=149720130002f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Sep 20 12:11:00 CST 2019, time=2019-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371934, encodeId=8f0613e1934ac, content=<a href='/topic/show?id=815e2e060ce' target=_blank style='color:#2F92EE;'>#便血#</a>, beContent=null, objectType=article, channel=null, 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time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487783, encodeId=b863148e783e5, content=<a href='/topic/show?id=f364e871840' target=_blank style='color:#2F92EE;'>#结直肠肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78718, encryptionId=f364e871840, topicName=结直肠肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78398366026, createdName=tamgche, createdTime=Sun May 19 08:11:00 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1928686, encodeId=a9c6192868637, content=<a href='/topic/show?id=7257e24943e' target=_blank style='color:#2F92EE;'>#直肠肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72494, encryptionId=7257e24943e, topicName=直肠肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=bnjfy, createdTime=Fri Apr 24 17:11:00 CST 2020, time=2020-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083702, encodeId=294f2083e02bc, content=<a href='/topic/show?id=685862555f0' target=_blank style='color:#2F92EE;'>#检测结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62555, encryptionId=685862555f0, topicName=检测结果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, 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  6. 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href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun May 19 08:11:00 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466857, encodeId=cf0f146685e43, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Sun May 19 08:11:00 CST 2019, time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487783, encodeId=b863148e783e5, content=<a href='/topic/show?id=f364e871840' target=_blank style='color:#2F92EE;'>#结直肠肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78718, encryptionId=f364e871840, topicName=结直肠肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78398366026, createdName=tamgche, createdTime=Sun May 19 08:11:00 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-19 huangdf
  7. 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time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487783, encodeId=b863148e783e5, content=<a href='/topic/show?id=f364e871840' target=_blank style='color:#2F92EE;'>#结直肠肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78718, encryptionId=f364e871840, topicName=结直肠肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78398366026, createdName=tamgche, createdTime=Sun May 19 08:11:00 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-19 zhenjiu124
  8. 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  9. 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time=2019-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487783, encodeId=b863148e783e5, content=<a href='/topic/show?id=f364e871840' target=_blank style='color:#2F92EE;'>#结直肠肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78718, encryptionId=f364e871840, topicName=结直肠肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78398366026, createdName=tamgche, createdTime=Sun May 19 08:11:00 CST 2019, time=2019-05-19, status=1, ipAttribution=)]
    2019-05-19 Homburg
  10. 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