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Stroke:血液透析患者缺血性卒中的发病率和病死率较高

2015-08-01 MedSci译 MedSci原创

    终末期肾病(ESRD)需要血液透析治疗,但该治疗方法比正常肾功能增加了10倍脑卒中的风险。来自一般人群的危险因素和管理策略的知识可能并不适用于这些终末期肾病患者。研究人员进行了一项大规模终末期肾病人群的研究来确定脑卒中的风险因素和预后。       从2007年1月1日到2012年12月31日所有接受血液透析的ESRD成年患者参与

终末期肾病(ESRD)需要血液透析治疗,但该治疗方法比正常肾功能增加了10倍脑卒中的风险。来自一般人群的危险因素和管理策略的知识可能并不适用于这些终末期肾病患者。研究人员进行了一项大规模终末期肾病人群的研究来确定脑卒中的风险因素和预后。
   
从2007年1月1日到2012年12月31日所有接受血液透析的ESRD成年患者参与了此次研究,他们的信息来自于电子病历。研究人员对与中风相关的变量通过生存分析进行了确定;并对人口学,临床,影像,和透析相关变量进行了评估,并确定了病例病死率。随访直到2013年12月31日。

该研究共确定了1382例患者(平均年龄60.5岁,58.5%为男性)。房颤的患病率为21.2%,59.4%为血液透析患者。其中160例(11.6%)在随访的3471病人年过程中经历了卒中(95%缺血性)。在普遍的患者中脑卒中发病率为41.5/1000病人年,在血液透析患者的发病率为50.1/1000病人年。研究人员在回归分析发现与卒中有关的因素是既往卒中史,糖尿病和开始肾脏替代治疗的年龄。房颤与中风无显著相关性,华法林并没有影响华法林治疗的患者卒中的风险。病死率在7天时为18.8%,28天时为26.9%,在卒中后365天为56.3%。

进行血液透析的ESRD患者脑卒中发病率和病死率较高。初始血液透析患者的卒中发生率最高。许多,但不是所有的重要危险因素在一般人群中与卒中发生相关,但与接受血液透析的患者的卒中发生无关。

原始出处:
Mark D. Findlay, MBChB, MRCP, Peter C. Thomson, MD, Rachael L. et al,Risk Factors of Ischemic Stroke and Subsequent Outcome in Patients Receiving Hemodialysis,Stroke, 2015.7.30

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    2016-01-13 Lynee劲飞扬

    期待

    0

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createdAvatar=, createdBy=623f1625122, createdName=maple243, createdTime=Tue Aug 18 15:36:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35208, encodeId=359d3520890, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:23:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34314, encodeId=3fef3431474, content=的确容易卒中, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Tue Aug 04 08:15:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262465, encodeId=c2db12624651a, content=<a href='/topic/show?id=a57589339a4' target=_blank style='color:#2F92EE;'>#血液透析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89339, encryptionId=a57589339a4, topicName=血液透析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570585, encodeId=b2f415e05850b, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1806019, encodeId=b0ff180601951, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun Jan 03 19:15:00 CST 2016, time=2016-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677400, encodeId=03e616e74003a, content=<a href='/topic/show?id=0101e089022' target=_blank style='color:#2F92EE;'>#病死率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70890, encryptionId=0101e089022, topicName=病死率)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=, createdBy=623f1625122, createdName=maple243, createdTime=Tue Aug 18 15:36:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35208, encodeId=359d3520890, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:23:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34314, encodeId=3fef3431474, content=的确容易卒中, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Tue Aug 04 08:15:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262465, encodeId=c2db12624651a, content=<a href='/topic/show?id=a57589339a4' target=_blank style='color:#2F92EE;'>#血液透析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89339, encryptionId=a57589339a4, topicName=血液透析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570585, encodeId=b2f415e05850b, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=)]
  6. 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createdAvatar=, createdBy=623f1625122, createdName=maple243, createdTime=Tue Aug 18 15:36:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35208, encodeId=359d3520890, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:23:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34314, encodeId=3fef3431474, content=的确容易卒中, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Tue Aug 04 08:15:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262465, encodeId=c2db12624651a, content=<a href='/topic/show?id=a57589339a4' target=_blank style='color:#2F92EE;'>#血液透析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89339, encryptionId=a57589339a4, topicName=血液透析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570585, encodeId=b2f415e05850b, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=)]
    2015-08-18 maple243

    所以透析过程中病情监测相当重要

    0

  7. 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createdAvatar=, createdBy=623f1625122, createdName=maple243, createdTime=Tue Aug 18 15:36:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35208, encodeId=359d3520890, content=期待有更多的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Fri Aug 07 16:23:00 CST 2015, time=2015-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34314, encodeId=3fef3431474, content=的确容易卒中, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Tue Aug 04 08:15:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262465, encodeId=c2db12624651a, content=<a href='/topic/show?id=a57589339a4' target=_blank style='color:#2F92EE;'>#血液透析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89339, encryptionId=a57589339a4, topicName=血液透析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570585, encodeId=b2f415e05850b, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=)]
    2015-08-07 hlycom3356

    期待有更多的研究

    0

  8. 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topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=)]
    2015-08-04 sundong

    的确容易卒中

    0

  9. 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createdName=sundong, createdTime=Tue Aug 04 08:15:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262465, encodeId=c2db12624651a, content=<a href='/topic/show?id=a57589339a4' target=_blank style='color:#2F92EE;'>#血液透析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89339, encryptionId=a57589339a4, topicName=血液透析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19c567, createdName=habb, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570585, encodeId=b2f415e05850b, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sun Aug 02 22:15:00 CST 2015, time=2015-08-02, status=1, ipAttribution=)]
    2015-08-02 habb
  10. 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