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N Engl J Med :减出好身材,保持更重要,这不是广告

2017-04-10 James 医之道

减出好身材,保持更重要。这是一句曾经非常流行的广告词。虽然市面上的减肥产品鱼龙混杂,很多掺杂了不允许添加的药品,很带来严重副作用。但这句广告词至少在字面上是完全正确的。

减出好身材,保持更重要。这是一句曾经非常流行的广告词。虽然市面上的减肥产品鱼龙混杂,很多掺杂了不允许添加的药品,很带来严重副作用。但这句广告词至少在字面上是完全正确的。

在一项最新的研究中,研究人员发现,在冠心病患者中,体重波动过大与脑卒中心肌梗死和死亡的风险升高有关。这项研究发表于4月6日的《新英格兰医学杂志》。此前已经有研究发现,对于没有冠心病的患者,体重波动过大是死亡和冠心病的危险因素。体重忽上忽下,就像一个上下滚动的溜溜球,所以这种现象又叫做“溜溜球现象”。

在这项最新的研究中,研究者随访了近1万名35~75岁之间的男性和女性冠心病患者,时间长达五年左右,监测体重和其他健康指标的变化。

研究结果显示,体重波动幅度最大者与体重波动幅度最小者相比,死亡、脑卒中、心肌梗死都升高。而且,在研究开始时已经超重和肥胖的患者中,这种“溜溜球现象”的风险更加明显,死亡、脑卒中、心肌梗死分别增加124%、136%和117%。也就是说这些冠心病患者在短短几年内发生这些负面结果的可能性要高一倍多。



图片来源:NEJM

如上图,患者按研究开始时体重指数正常、超重、肥胖分成三组,每一组中,体重波动大的患者(用浅紫色表示)发生的血管事件都多于体重波动小的患者(深紫色)。

既然减肥以后再反弹会有这么不好的后果,那是不是干脆就不要减肥呢?这也是不对的。因为超重和肥胖本身就是血管疾病、糖尿病、癌症等疾病的危险因素。

这项研究并没有阐明原因,因为罪魁祸首也有可能是原先存在的心脏问题。研究人员希望能进一步研究这种相关性。

《纽约时报》引用了研究第一作者、纽约大学医学院Sripal Bangalore博士的话:“减肥很重要,但我们的数据告诉大家还得保持才行。”嗯,其实就是“减出好身材,保持更重要”这句广告词的学术版。

不过,这里再次提醒,减肥主要靠饮食和运动,靠坚持健康的生活方式。如果要使用药物,那么一定要在医生指导下才行,千万不能光听广告。

原始出处:

Sripal Bangalore, et al. Body-Weight Fluctuations and Outcomes in Coronary Disease. N Engl J Med 2017; 376:1332-1340

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    2018-02-26 zhaojie88
  2. [GetPortalCommentsPageByObjectIdResponse(id=2081351, encodeId=6e2a2081351f2, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Feb 26 09:21:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785451, encodeId=d49e1e85451f7, content=<a href='/topic/show?id=34b86e91f9' target=_blank style='color:#2F92EE;'>#Engl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6791, encryptionId=34b86e91f9, topicName=Engl)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sun Aug 06 01:21:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186999, encodeId=f95c18699928, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Apr 13 06:20:18 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186976, encodeId=0dc71869e696, content=确实如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Thu Apr 13 00:52:18 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186836, encodeId=03d51868368d, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Wed Apr 12 09:28:10 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607376, encodeId=3454160e37638, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Apr 12 00:21:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186403, encodeId=7a78186403e1, content=体重忽上忽下,就像一个上下滚动的溜溜球,所以这种现象又叫做“溜溜球现象”。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Mon Apr 10 10:52:37 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-08-06 医者仁心
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    2017-04-13 ylzr123

    好文,值得点赞,更值得收藏!慢慢领会学习的。

    0

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    2017-04-13 qjzhai1623

    确实如此

    0

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    2017-04-12 186****0580(小山羊)

    学习了谢谢了。

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=2081351, encodeId=6e2a2081351f2, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Feb 26 09:21:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785451, encodeId=d49e1e85451f7, content=<a href='/topic/show?id=34b86e91f9' target=_blank style='color:#2F92EE;'>#Engl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6791, encryptionId=34b86e91f9, topicName=Engl)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sun Aug 06 01:21:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186999, encodeId=f95c18699928, content=好文,值得点赞,更值得收藏!慢慢领会学习的。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Apr 13 06:20:18 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186976, encodeId=0dc71869e696, content=确实如此, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Thu Apr 13 00:52:18 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186836, encodeId=03d51868368d, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Wed Apr 12 09:28:10 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607376, encodeId=3454160e37638, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Apr 12 00:21:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186403, encodeId=7a78186403e1, content=体重忽上忽下,就像一个上下滚动的溜溜球,所以这种现象又叫做“溜溜球现象”。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Mon Apr 10 10:52:37 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-10 榄枷檬

    体重忽上忽下,就像一个上下滚动的溜溜球,所以这种现象又叫做“溜溜球现象”。

    0

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