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Sci Rep:基于TPMS的仿生骨组织工程多孔支架建模方法

2018-09-22 MedSci MedSci原创

在骨缺损修复领域,梯度多孔支架因其为促进组织再生提供了更好的环境而受到越来越多的关注。在这项研究中,我们提出了一种基于TPMS(三重周期最小表面)和SF(乙状结肠功能)制备仿生多孔支架的有效方法。 首先,通过分析CT扫描确定兔股骨的几个区域的皮质骨形态特征(例如,孔径和分布)。 有限元方法评估这些相应区域的骨的机械性质。这些结果用于将不同的TPMS子结构置于具有平滑过渡的一个支架域中。优化

在骨缺损修复领域,梯度多孔支架因其为促进组织再生提供了更好的环境而受到越来越多的关注。在这项研究中,我们提出了一种基于TPMS(三重周期最小表面)和SF(乙状结肠功能)制备仿生多孔支架的有效方法。

首先,通过分析CT扫描确定兔股骨的几个区域的皮质骨形态特征(例如,孔径和分布)。 有限元方法评估这些相应区域的骨的机械性质。这些结果用于将不同的TPMS子结构置于具有平滑过渡的一个支架域中。优化支架的几何参数以匹配人骨的弹性性质。

利用该提出的方法,可以通过增材制造方法设计和生产功能梯度多孔支架。

原始出处:

Shi J, Zhu L, et al., A TPMS-based method for modeling porous scaffolds for bionic bone tissue engineering. Sci Rep. 2018 May 9;8(1):7395. doi: 10.1038/s41598-018-25750-9.

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