Heart：高红细胞分布宽度（RDW）可能与急性冠脉事件的病死率有关

2014-04-27 MedSci MedSci原创

以前有研究显示高红细胞分布宽度（red cell distribution width，RDW)与心血管疾病患者预后密切相关。此次研究者进一步研究RDW与急性冠脉事件（acute coronary events，CEs)和第一次心血事件引发的病死率（fatal outcome）的相关性。此项研究发表在最新一期的Heart上。由瑞典Borné Y教授发起进行研究。本项研究共纳入瑞典国家队列，是参

以前有研究显示高红细胞分布宽度（red cell distribution width，RDW)与心血管疾病患者预后密切相关。此次研究者进一步研究RDW与急性冠脉事件（acute coronary events，CEs)和第一次心血事件引发的病死率（fatal outcome）的相关性。此项研究发表在最新一期的Heart上。由瑞典Borné Y教授发起进行研究。

本项研究共纳入瑞典国家队列，是参与1991-1996年Malmö Diet and Cancer study研究的人群，共26820位45-73岁的患者（其中61.6%为女性），既往无心梗病史或卒中史。COX回归分析发现RDW与急性冠脉事件密切相关，在平均14年的随访中发现，1995例患者有第一次急性冠脉事件，其中415例同一天死亡，另外86例在28天内死亡。以及1494位为非致死性（生存超过28天）。校正变量后，基线的RDW与致死性冠脉事件显著相关(HR 1.82, CI 1.35 to 2.44)，但与非致死性冠脉事件不相关(HR 0.96, CI 0.82 to 1.12).

MedSci编辑进一步查阅资料发现，在既往研究中，还发现RDW与首次静脉血栓发生同样密切相关，甚至也与心衰竭和心梗有关，这些结果提示，RDW与冠脉事件造成的死亡，可能有更深的背后关联。

原始出处：

Borné Y, Smith JG, Melander O, Engström G.Red cell distribution width in relation to incidence of coronary events and case fatality rates: a population-based cohort study.Heart. 2014 Apr 23. doi: 10.1136/heartjnl-2013-305028

相关文献：

Zöller B, Melander O, Svensson P, Engström G.Red cell distribution width and risk for venous thromboembolism: a population-based cohort study.Thromb Res. 2014 Mar;133(3):334-9

Akin F, Köse N, Ayça B, Katkat F, Duran M, Uysal OK, Arinc H.Relation between red cell distribution width and severity of coronary artery disease in patients with acute myocardial infarction.Angiology. 2013 Nov;64(8):592-6.

Makhoul BF, Khourieh A, Kaplan M, Bahouth F, Aronson D, Azzam ZS.Relation between changes in red cell distribution width and clinical outcomes in acute decompensated heart failure.Int J Cardiol. 2013 Aug 20;167(4):1412-6

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2015-05-21 bird521

正是我想了解的内容！赞

118 0
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2014-10-18 soongzhihua

#病死率#

73 0
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2014-10-02 一闲

#红细胞分布宽度#

64 0
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2014-05-06 ms3117646317107274

#冠脉事件#

63 0
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2014-05-03 sence

什么造成了RDW增宽，同时影响了心脏病预后；或是RDW增宽本身也影响了疾病预后？一个入院必查的最普通检查包含了意想不到的信息，后续研究值得期待。

151 0
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2014-04-29 kord1982

#红细胞#

63 0
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2014-04-29 zhaojie88

#ART#

57 0
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2014-04-29 爆笑小医

#HEART#

46 0
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2014-04-27 218.25.35.158

好文章！！值得学习

123 0

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