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Oral Oncol:自1970年至2011年间儿童和青少年口腔癌、唾液腺癌以及咽癌的流行病学分析

2017-04-03 MedSci MedSci原创

在过去的10年间,报道称口腔癌和咽癌的发病年龄逐渐减小。但是大多数经过同行评阅的文献报道发现,在0-19岁口腔癌和咽癌的发生局限于特殊的肿瘤部位和/或类型,又或者只占很小的一部分。这篇研究是为了揭示0-19岁年轻患者口腔癌、唾液腺癌和咽癌(OSPC)的特点,以便临床医师提高对年轻个体此类疾病的认识。

在过去的10年间,报道称口腔癌和咽癌的发病年龄逐渐减小。但是大多数经过同行评阅的文献报道发现,在0-19岁口腔癌和咽癌的发生局限于特殊的肿瘤部位和/或类型,又或者只占很小的一部分。这篇研究是为了揭示0-19岁年轻患者口腔癌、唾液腺癌和咽癌(OSPC)的特点,以便临床医师提高对年轻个体此类疾病的认识。

研究数据来源于以色列国家肿瘤注册中心1970年至2011年间的数据库,观察指标包括患者的年龄、性别、肿瘤部位和类型。数据分析使用IBM SPSS、Winpepi software和Joinpoint Regression Program。alpha<0.05被认为具有统计学意义。

结果显示,在13863例OSPC病例中筛选出0-19岁的为2.6%(N=357)。男女比例为1.5:1。在1991年至2011年间的肿瘤确诊率减少,并且没有明显的性别差异。鼻咽为肿瘤发生率最高的部位(42.3%),其次为唾液腺(20.5%),并且高发于14-19岁。扁导体和咽部其他位置的肿瘤高发于0-13岁。主要的肿瘤类型为淋巴瘤(20.7%)和癌(19.9%)。

结论:在过去的40年间,OSPC的一般特征未发生明显改变。这可能意味着环境因素对肿瘤的发生没有影响。另外,男性发病率要高于女性,并且发生在鼻咽部的恶心肿瘤很可能受到遗传因素的影响。因此,保健医疗工作者需要熟知青少年肿瘤好发部位以及类型,以便早发现早治疗。

原始出处

Levi S1, Zini A, et al. Epidemiology of oral, salivary gland and pharyngeal cancer in children and adolescents between 1970 and 2011. Oral Oncol. 2017 Apr;67:89-94. doi: 10.1016/j.oraloncology.2017.02.010.

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    2017-05-06 minlingfeng
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  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Tue Apr 04 06:56:39 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184950, encodeId=d7011849506d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Apr 04 00:05:00 CST 2017, time=2017-04-04, status=1, ipAttribution=)]
    2018-02-04 小几洁
  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Tue Apr 04 06:56:39 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184950, encodeId=d7011849506d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Apr 04 00:05:00 CST 2017, time=2017-04-04, status=1, ipAttribution=)]
    2017-04-28 flysky120

    学习知识,儿童还有这样的疾病,没有遇见过

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Tue Apr 04 06:56:39 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184950, encodeId=d7011849506d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Apr 04 00:05:00 CST 2017, time=2017-04-04, status=1, ipAttribution=)]
    2017-04-05 xugumin
  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Tue Apr 04 06:56:39 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184950, encodeId=d7011849506d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Apr 04 00:05:00 CST 2017, time=2017-04-04, status=1, ipAttribution=)]
    2017-04-04 医艺依意

    流行病学研究真的很难

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Tue Apr 04 06:56:39 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184950, encodeId=d7011849506d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Apr 04 00:05:00 CST 2017, time=2017-04-04, status=1, ipAttribution=)]
    2017-04-04 卡圣

    谢谢分享,学习了

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Tue Apr 04 06:56:39 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184950, encodeId=d7011849506d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Apr 04 00:05:00 CST 2017, time=2017-04-04, status=1, ipAttribution=)]
    2017-04-04 ann y

    过去的40年间,OSPC的一般特征未发生明显改变。这可能意味着环境因素对肿瘤的发生没有影响

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Tue Apr 04 06:56:39 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184950, encodeId=d7011849506d, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Apr 04 00:05:00 CST 2017, time=2017-04-04, status=1, ipAttribution=)]
    2017-04-04 飛歌

    学习了很有用

    0

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