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Hypertension:婴儿出生体重和增长速度与心肌代谢风险参数相关

2014-04-04 高晓方 译 医学论坛网

西班牙一项研究表明,婴儿早期体重增长加速可能加剧低出生体重对血压和代谢的影响。论文于3月31日在线发表于《高血压》(Hypertension)。 此项研究共纳入139例正常妊娠后足月分娩的新生儿。新生儿均无围产期疾病,并且依据出生体重被分为小于、适于和大于胎龄儿。在出生后第二天进行初始评估之后,在6个月和第2、5年时进行随访。每次随访均测定人体测量学指标和血压,并在5岁时实施代谢评估。 结果显

西班牙一项研究表明,婴儿早期体重增长加速可能加剧低出生体重对血压和代谢的影响。论文于3月31日在线发表于《高血压》(Hypertension)。

此项研究共纳入139例正常妊娠后足月分娩的新生儿。新生儿均无围产期疾病,并且依据出生体重被分为小于、适于和大于胎龄儿。在出生后第二天进行初始评估之后,在6个月和第2、5年时进行随访。每次随访均测定人体测量学指标和血压,并在5岁时实施代谢评估。

结果显示,在各出生体重组新生儿中,孕母的年龄、吸烟状况和妊娠期间体重增长均无差异。出生体重为出生时收缩压的阳性决定因素。其后,当前体重为最强决定因素,在2岁时具有统计学意义并且影响力逐步增加。5岁时,胰岛素、稳态模型评估指数和甘油三酯由出生体重、当前体重和出生后体重增长所决定。出生体重与高密度脂蛋白胆固醇(HDL-C)呈正相关,并与尿酸呈负相关。即便在幼儿期亦可观察到胰岛素、血压值和尿酸的正相关性。

原始出处:


Lurbe E1, Garcia-Vicent C, Torro MI, Aguilar F, Redon J.Associations of Birth Weight and Postnatal Weight Gain With Cardiometabolic Risk Parameters at 5 Years of Age.Hypertension. 2014 Mar 31.



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