Sleep：揭示调节食欲的激素的作用方式因性别而异

刊登在国际杂志Sleep上的一篇研究报告指出，增加成人的睡眠量可以导致其食物摄取量降低，而且在男性和女性中和食物摄取相关的激素分泌过程也表现出不同。研究者Marie-Pierre St-Onge博士说，在健康正常体重的参与者中，通过限制其睡眠就会限制其代谢风险因子的效应，而且会通过在男、女机体中不同的调节荷尔蒙分泌的方式来影响其食物的摄取量。

研究者针对睡眠对葡萄糖、胰岛素以及瘦素的影响，以及饥饿刺激激素葛瑞林和GLP-1因性别而异开展了研究，本项研究主要对27个正常体重、年龄在30至45岁之间的男性、女性参与者，在睡眠持续时间、葡萄糖代谢异常以及激素调节食欲上进行了深入研究。参与者空腹，处于两种睡眠状态：短时间（4小时）和习惯性睡眠（9小时）。结果表明，短时睡眠可以增加男性而非女性的葛瑞林水平，但是却增加了女性的GLP-1水平而不增加男性的GLP-1水平。结果揭示了短时睡眠期间，吃的太饱常见的易感性和男性食欲增加相关、和女性吃饱感觉降低相关。

研究者表示，我们的研究结果指出了睡眠持续时间和能量平衡调节之间的复杂性关系，处于能量平衡状态，无论个体处于体重减轻还是过重的状态，对于其代谢和荷尔蒙的效应都非常关键。

这项研究是针对减小睡眠对和饮食摄入相关的激素调节的效应相关的大型控制性的临床调查研究，研究结果为睡眠持续时间在能量摄入和体重控制上所扮演的角色提供了相关依据。

编译自：Sleep Duration Affects Hunger Differently in Men and Women

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• Sleep：揭示调节食欲的激素的作用方式因性别而异
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• JNCI：雌激素联合黄体酮会增高乳腺癌发病率
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PMID:

Short Sleep Duration, Glucose Dysregulation and Hormonal Regulation of Appetite in Men and Women

Marie-Pierre St-Onge, PhD1,2; Majella O'Keeffe, PhD1; Amy L. Roberts, MSc1; Arindam RoyChoudhury, PhD3; Blandine Laferrère, MD1,2

Study Objective: To determine the hormonal effects of reducing sleep duration under controlled feeding conditions. Design: Randomized, crossover study. Setting: Inpatient. Participants: Twenty-seven normal weight, 30- to 45-yr-old men and women habitually sleeping 7-9 hr/night. Intervention: Participants were studied under two sleep conditions: short (4 hr in bed) or habitual (9 hr in bed) sleep. A controlled diet was provided for each 4-day study period. Measurements and Results: Fasting blood samples were obtained daily and frequent blood samples were obtained throughout day 4. The main outcomes measures included glucose, insulin, leptin, ghrelin, adiponectin, total glucagon-like peptide 1 (GLP-1) and peptide YY3-36 (PYY3-36) concentrations. Body weights were reduced by 2.2 ± 0.4 lb and 1.7 ± 0.4 lb during the habitual and short sleep phases, respectively (both P < 0.0001). There was no effect of sleep duration on glucose, insulin, and leptin profiles (all P > 0.05). Ghrelin and GLP-1 responses differed by sex. Short sleep increased fasting (P = 0.054) and morning (08:00-12:00) (P = 0.042) total ghrelin in men but not women. The reverse was observed for GLP-1: afternoon levels (12:30-19:00) were lower (P = 0.016) after short sleep compared with habitual sleep in women but not men. Conclusions: These data suggest that, in the context of negative energy balance, short sleep does not lead to a state of increased insulin resistance, but may predispose to overeating via separate mechanisms in men and women. Clinical Trial Information: Trial registration on http://www.clinicaltrials.gov. #NCT00935402. Citation: St-Onge MP; O'Keeffe M; Roberts AL; RoyChoudhury A; Laferrère B. Short sleep duration, glucose dysregulation and hormonal regulation of appetite in men and women. SLEEP 2012;35(11):1503-1510.