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Hypertension:动脉硬化、动脉粥样硬化和心血管健康与心血管疾病发病率的关系

2021-10-09 MedSci原创 MedSci原创

该研究的结果表明,同时伴有动脉粥样硬化、动脉硬化和心血管健康状况不佳会大大增加心血管疾病的风险,而它们的缺失则表明风险较低。

衰老与亚临床动脉粥样硬化和动脉壁硬化的患病率增加有关。理想的血管健康(空腹血糖、胆固醇、静息血压、体重指数、不吸烟、良好的饮食质量和定期体育活动的最佳水平)可以缓解这两种合并疾病。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员假设亚临床动脉粥样硬化(冠状动脉钙化)、动脉硬化(较高的颈股动脉脉搏波速度)和心血管健康欠佳与心血管疾病风险增加相关。

研究人员在基于社区的弗雷明汉心脏研究队列(N=2580,平均年龄为52岁,49%女性)中检验了这一假设,并根据(1)有无冠状动脉钙、(2)较高(性别特异性中位数)颈股脉搏波速度、(3)心血管健康不佳(0-7分)对参与者进行分类。因此,参与者可分为都没有(对照组)、1个、2个或3个不佳指标。研究人员使用Cox回归将不佳指标(0-3)的数量与随访期间(中位数14年)的心血管疾病发生率联系起来。

伴有0至3个不佳指标个体的心血管疾病发病率分别为1.93(95%CI为1.28-2.90)、4.68(95%CI为3.48-6.29)、8.93(95%CI为6.99-11.41)和18.26(95%CI为14.65–22.77)/1000人年。与对照组相比,相应的心血管疾病多变量调整风险比分别为1.81、2.18和3.71(均P<0.05)。

由此可见,该研究的结果表明,同时伴有动脉粥样硬化、动脉硬化和心血管健康状况不佳会大大增加心血管疾病的风险,而它们的缺失则表明风险较低。

原始出处:

Ramachandran S. Vasan.et al.Arteriosclerosis, Atherosclerosis, and Cardiovascular Health: Joint Relations to the Incidence of Cardiovascular Disease.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.18075

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  8. 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time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058943, encodeId=688a105894330, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Oct 09 13:05:17 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058831, encodeId=5d8e105883117, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210123/de3e3cb777b342e0a1c1276de5bf1b9a/9325fbaec7b940728d61b380ff227dde.jpg, createdBy=46a42697416, 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    2021-10-09 医鸣惊人

    认真学习了

    0

  9. 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time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058943, encodeId=688a105894330, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Oct 09 13:05:17 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058831, encodeId=5d8e105883117, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210123/de3e3cb777b342e0a1c1276de5bf1b9a/9325fbaec7b940728d61b380ff227dde.jpg, createdBy=46a42697416, createdName=ent_xunmeng1987, createdTime=Sat Oct 09 09:46:46 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058822, encodeId=17651058822d4, content=心血管疾病风险很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201117/a59b28b63198490ea85b1e5b3d13c2bf/1b1e0d03ca22467d8120443ebbc24c04.jpg, createdBy=35d22207591, createdName=zhangxiang, createdTime=Sat Oct 09 09:34:45 CST 2021, time=2021-10-09, status=1, ipAttribution=)]
    2021-10-09 ent_xunmeng1987

    学习了

    0

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createdName=ent_xunmeng1987, createdTime=Sat Oct 09 09:46:46 CST 2021, time=2021-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1058822, encodeId=17651058822d4, content=心血管疾病风险很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201117/a59b28b63198490ea85b1e5b3d13c2bf/1b1e0d03ca22467d8120443ebbc24c04.jpg, createdBy=35d22207591, createdName=zhangxiang, createdTime=Sat Oct 09 09:34:45 CST 2021, time=2021-10-09, status=1, ipAttribution=)]
    2021-10-09 zhangxiang

    心血管疾病风险很多

    0

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