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Dermatol Surg:这样治疗非黑素瘤皮肤癌是有效的

2016-08-04 Mechront 译 MedSci原创

根据最近的研究数据,使用激光烧蚀分数-局部氟尿嘧啶辅助治疗浅表基底细胞癌(BCC)和鳞状细胞原位癌(SCC)是有效的无创治疗手段。来自波士顿医疗中心皮肤科的Sarah H. Hsu博士和同事在以前的研究中发现了该治疗方式的短期疗效,但是长期结果仍未知。因此他们对30例原发性浅表型BCC或直径小于2cm的SCC患者使用了激光烧蚀分数和皮下外用5%的5-氟尿嘧啶7天。平均随访时间为15个月,26名患者

根据最近的研究数据,使用激光烧蚀分数-局部氟尿嘧啶辅助治疗浅表基底细胞癌(BCC)和鳞状细胞原位癌(SCC)是有效的无创治疗手段。

来自波士顿医疗中心皮肤科的Sarah H. Hsu博士和同事在以前的研究中发现了该治疗方式的短期疗效,但是长期结果仍未知。因此他们对30例原发性浅表型BCC或直径小于2cm的SCC患者使用了激光烧蚀分数和皮下外用5%的5-氟尿嘧啶7天。平均随访时间为15个月,26名患者中有20名在治疗4-8周时间里,进行了刮活组织检查,以验证组织间隙。

数据显示,总的治疗成功率为79%(95% CI,67-96)。SCC原位癌患者的成功率为92%,浅表BCC患者的成功率为67%。肿瘤位置或大小对治疗结果影响不显著。

研究人员写道,“大多数的治疗失败发生在治疗4-8周内,因此在一定程度上,可以通过治疗的初步反应预测长期的结果。随着人口老龄化,非黑素瘤皮肤癌的发生率增加,找到更加方便和符合成本效益的治疗方案是必要的,尤其是对复发低风险的浅表肿瘤。”

原始出处:

Ablative fractional laser with topical fluorouracil effective for some nonmelanoma skin cancers.Healio.August 3, 2016

Hsu S.H., et al. Ablative Fractional Laser-Assisted Topical Fluorouracil for the Treatment of Superficial Basal Cell Carcinoma and Squamous Cell Carcinoma In Situ: A Follow-Up Study..Dermatol Surg. 2016;doi:10.1097/DSS.0000000000000814.

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    2016-08-05 doctorJiangchao

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    2016-08-05 doctorJiangchao

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