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ASCO2017:多吃坚果可能降低结肠癌患者复发、死亡的风险

2017-05-19 tulip1999 来宝网

每周食用至少2盎司坚果可显着降低III期结肠癌患者的癌症复发风险及一半以上的死亡风险。 这项最新研究成果预计将于下月在芝加哥召开的美国临床肿瘤学会(ASCO)2017年会上公开发布。

每周食用至少2盎司坚果可显着降低III期结肠癌患者的癌症复发风险及一半以上的死亡风险。

这项最新研究成果预计将于下月在芝加哥召开的美国临床肿瘤学会(ASCO)2017年会上公开发布。

根据美国癌症协会的数据显示,美国今年大约会出现95,520例结肠癌新增病例。

对于癌细胞已扩散至邻近淋巴结或组织的III期结肠癌患者来说,其5年生存率大约是53%-89%。

然而,这项最新研究表明,定期食用坚果可降低III期结肠癌治疗后的复发率,并可提高患者的生存率。

腰果、榛子、胡桃、杏仁、核桃都属于树坚果,已有大量研究证明其潜在的健康益处。

在这项最新研究中,主要作者,来自波士顿达纳-法伯癌症研究所的Temidayo Fadelu博士及其同事开始着手研究通吃所有坚果或只吃树坚果是否有利于结肠癌患者。

研究人员对826例III期结肠癌患者的数据进行了分析。这些患者需要完成饮食问卷。Fadelu博士及其同事用这些信息算出他们坚果的每周摄入量,看看是否与结肠癌的复发风险和生存率有关。

与不吃坚果的患者相比,每周至少食用2盎司坚果的患者其结肠癌复发风险降低了42%,死亡风险降低了57%。

然而,经过更进一步的研究之后,研究人员发现,只有食用树坚果才会有这些益处。每周至少食用2盎司树坚果的患者其结肠癌复发风险降低了46%,而死亡风险降低了53%。

食用花生或花生酱与癌症复发或死亡显着减少无关。

基于以上研究结果,Fadelu博士及其同事认为,结肠癌患者可从包含树坚果在内的饮食中受益。

“应强调的是,作者并没有建议能够用坚果来代替结肠癌的标准化疗和其他治疗方法,这些治疗方法可以大大提高结肠癌患者的生存率。”

“结肠癌患者应该乐观一些,应该多吃健的饮食,包括树坚果,这不仅可以使他们更健康,还可能进一步减少癌症复发的几率。”美国临床肿瘤学会主席David Hayes博士如是说。

原始出处:

Temidayo Fadelu, Donna Niedzwiecki, et al. Nut consumption and survival in stage III colon cancer patients: Results from CALGB 89803 (Alliance). 2017 ASCO Annual Meeting. Abstract No:3517

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    2017-11-29 quxin068
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    2017-06-05 jyzxjiangqin

    多吃坚果可以降低结肠癌患者复发风险。

    0

  3. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri May 19 16:02:55 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200003, encodeId=872120000347, content=哇!这个效果比其它报道都高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Fri May 19 14:04:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199994, encodeId=abd919999455, content=坚果还是挺好的,就是太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, 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    2017-05-29 jyzxjiangqin

    多吃坚果可能降低结肠癌患者死亡风险。

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri May 19 16:02:55 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200003, encodeId=872120000347, content=哇!这个效果比其它报道都高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Fri May 19 14:04:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199994, encodeId=abd919999455, content=坚果还是挺好的,就是太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri May 19 13:16:27 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-22 临风淑玉

    好的,可以为吃找借口

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri May 19 16:02:55 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200003, encodeId=872120000347, content=哇!这个效果比其它报道都高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Fri May 19 14:04:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199994, encodeId=abd919999455, content=坚果还是挺好的,就是太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri May 19 13:16:27 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-22 lou.minghong

    也不是越吃多越好

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri May 19 13:16:27 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-20 1e10c84am36(暂无匿称)

    文章很好,拜读了

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri May 19 16:02:55 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200003, encodeId=872120000347, content=哇!这个效果比其它报道都高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Fri May 19 14:04:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199994, encodeId=abd919999455, content=坚果还是挺好的,就是太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri May 19 13:16:27 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-20 jyzxjiangqin

    多吃坚果可能降低结肠癌患者复发。

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri May 19 16:02:55 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200003, encodeId=872120000347, content=哇!这个效果比其它报道都高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Fri May 19 14:04:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199994, encodeId=abd919999455, content=坚果还是挺好的,就是太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri May 19 13:16:27 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-19 luominglian113

    学习了,谢谢分享

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri May 19 16:02:55 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200003, encodeId=872120000347, content=哇!这个效果比其它报道都高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Fri May 19 14:04:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199994, encodeId=abd919999455, content=坚果还是挺好的,就是太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri May 19 13:16:27 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-19 cqykthl

    哇!这个效果比其它报道都高。

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri May 19 16:02:55 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200003, encodeId=872120000347, content=哇!这个效果比其它报道都高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Fri May 19 14:04:14 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199994, encodeId=abd919999455, content=坚果还是挺好的,就是太贵了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Fri May 19 13:16:27 CST 2017, time=2017-05-19, status=1, ipAttribution=)]
    2017-05-19 Mr.Li先生

    坚果还是挺好的,就是太贵了

    0

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Cancer Res:复旦大学管坤良研究组发表结肠癌发生发展调控机制研究进展

2017年5月1日,国际著名肿瘤学杂志《Cancer Research》上在线发表了复旦大学生物医学研究院分子与细胞生物学实验室管坤良研究组发表的一篇科研论文,论文题为《内皮素通过激活YAP/TAZ信号促进结直肠癌发生》(“Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ”),研究报道了调节血管收缩的细胞因子内皮素

Gastroenterology:他汀类药物在结肠癌患者生存中的应用

他汀类药物与结肠癌风险降低相关,对于BMP通路完整或KRAS突变患者其效果更为显著,该结果还需要进一步的临床试验确证

SCI REP:DADS下调LIMK1-ADF/cofilin抑制结肠癌迁移与侵袭

结肠癌是人类最常见的恶性肿瘤之一,发病率及死亡率不断增长。晚期结肠癌预后不良的主要原因是对化疗的抵抗以及5年内约50%结肠癌患者出现的远处转移。因此探索结肠癌转移的分子机制对结肠癌的治疗至关重要。大蒜不仅是一种颇受欢迎的食物,还具有一定的抗肿瘤作用。大蒜成分diallyl disulfide(DADS)是大蒜具有抗肿瘤作用的主要原因。已有研究证明沉默LIMK1可以显着增强DADS对结肠癌细胞迁移侵

JAMA Surg:结肠癌手术部位感染风险因素

多种因素会导致结肠癌术后感染风险增加

Cancer Lett:厦门大学陈清西课题组揭示视黄酸受体α促进结肠癌细胞生长的分子机制

近期,厦门大学陈清西教授课题组在肿瘤研究领域重要期刊《Cancer Letters》杂志在线发表了 “Oncogenic retinoic acid receptor α promotes human colorectal cancer growth through simultaneously regulating p21 transcription and GSK3β/β-catenin si

Nature:日本发现大肠癌复发机理

日本庆应大学医学部的研究团队采用患者身上提取的结肠癌细胞进行培养,再用干细胞特有的 LGR5 遗传因子进行荧光标识,然后移植到小鼠身上,进行治疗实验。结果发现,虽然药物可以杀死干细胞,使癌细胞停止增长,但是停止用药后,干细胞会再次出现,导致癌细胞继续扩大。这是由于从干细胞分化来的短命细胞会发生“返祖”现象,使干细胞重新复活。正常状态下的肠道中,存在着干细胞和短寿命细胞。干细胞在自己增殖的同时会分化

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