Science：科学家找到让伤口愈合不留疤的方法

2017-01-10 文姜生物探索

科学家们最近找到一种让伤口愈合为再生的皮肤而非疤痕组织的新方法，这种方法可以将伤口处最常见的细胞类型转变成脂肪细胞，在该研究之前这种转变在人体上被认为不可能发生。相关研究结果发表在1月5日的Science上。科学家们最近找到一种让伤口愈合为再生的皮肤而非疤痕组织的新方法，这种方法可以将伤口处最常见的细胞类型转变成脂肪细胞，在该研究之前这种转变在人体上被认为不可能发生。相关研究结果发表在1月5日的S

科学家们最近找到一种让伤口愈合为再生的皮肤而非疤痕组织的新方法，这种方法可以将伤口处最常见的细胞类型转变成脂肪细胞，在该研究之前这种转变在人体上被认为不可能发生。相关研究结果发表在1月5日的Science上。

肌成纤维细胞转化为脂肪细胞

在正常情况下皮肤中有脂肪细胞存在，但是当伤口愈合为疤痕脂肪细胞就会消失。伤口愈合过程的中最常见的一类细胞是肌成纤维细胞，它被认为只能形成疤痕组织。疤痕组织中没有任何毛囊，因此看起来与其余正常皮肤不同。研究人员以这些特性为基础，将已经存在的肌成纤维细胞转化为不产生疤痕的脂肪细胞。

通讯作者，宾夕法尼亚大学医学院的George Cotsarelis大夫说：“基本上，我们可以调控伤口的愈合导致皮肤再生，而不是疤痕。秘诀是先产生毛囊，之后脂肪会响应来自毛囊的信号再生。”

BMP的因子诱导了脂肪细胞

该研究显示毛发和脂肪各自发育，但是发育过程并非完全独立进行。首先形成毛囊，然后Cotsarelis实验室的研究人员发现了毛囊形成所必需的一些因子，现在他们又发现一些由再生毛囊产生的因子可以将周围的肌成纤维细胞转变成脂肪细胞而非形成疤痕。没有新的毛发形成脂肪细胞也不会形成，一旦形成毛发就会随之形成脂肪细胞，并且与已经存在的脂肪细胞没有区别，愈合的伤口就会看起来非常自然而不会留下疤痕。

当他们检查到底毛囊产生了什么信号诱导了脂肪细胞的形成的问题时，研究人员发现一种叫做BMP的因子发挥了重要作用，引导肌成纤维细胞变成脂肪细胞。Cotsarelis大夫说：“通常来说，肌成纤维细胞无法变成另外一种类型的细胞。但是我们的工作表明我们可以影响这些细胞使其高效稳定地转变成脂肪细胞。”这在培养的小鼠和人类疤痕细胞上都会发生。

皮肤病领域具有革命性的潜力

这些发现在皮肤病领域具有革命性的潜力。第一和最明显的用途是开发一种治疗方法将肌成纤维细胞转变成脂肪细胞，帮助伤口愈合并且不会形成疤痕。

皮肤组织中的脂肪细胞增加不仅对伤口愈合有帮助，脂肪细胞损失也是其他一些疾病的常见并发症，特别是HIV的治疗，目前还没有有效的解决办法。除此之外，随着衰老过程的发生，皮肤中的脂肪细胞也会逐渐损失（尤其是在脸上），导致永久的、深深的皱纹形成，这是抗衰老治疗无法很好解决的问题。

Cotsarelis大夫说：“我们的研究成果可能获得一个在皮肤皱纹中再生脂肪细胞的新策略，让我们创造新的抗衰老治疗品牌。”

原始出处：

Maksim V. Plikus1,2,*, Christian F. Guerrero-Juarez2, Mayumi Ito3, Yun Rose Li4, Priya H. Dedhia5, Ying Zheng1, Mengle Shao6, Denise L. Gay1,7, Raul Ramos2, Tsai-Ching His2, Ji Won Oh2,8, Xiaojie Wang2, Amanda Ramirez2, Sara E. Konopelski2, Arijh Elzein2, Anne Wang1, Rarinthip June Supapannachart1, Hye-Lim Lee2, Chae Ho Lim3, Arben Nace1, Amy Guo1, Elsa Treffeisen1, Thomas Andl9, Ricardo N. Ramirez2, Rabi Murad2, Stefan Offermanns10, Daniel Metzger11, Pierre Chambon12, Alan D. Widgerow13, Tai-Lan Tuan14, Ali Mortazavi2, Rana K. Gupta6, Bruce A. Hamilton15, Sarah E. Millar1, Patrick Seale4,16, Warren S. Pear5, Mitchell A. Lazar4,17, George Cotsarelis1,*.Regeneration of fat cells from myofibroblasts during wound healing.Science.05 Jan 2017

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2017-01-12 chenzhuanggui

#伤口愈合#

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2017-01-12 jichang

#SCIE#

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2017-01-11 为了宝宝

赶紧应用临床！迫不及待啦

5 0
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2017-01-11 1df01bccm39(暂无匿称)

这属于革命性的技术革新

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2017-01-10 xiaotaiyang1

了解一下

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2017-01-10 1e1e0321m25(暂无匿称)

皮肤学的重大发现

89 0
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2017-01-10 ys2323

新的希望！

83 0
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2017-01-10 半夏微凉

希望早日应用到临床。

0 0
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2017-01-10 1e1a1fdfm09(暂无匿称)

学习，瘢痕终于看到曙光了

52 0
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2017-01-10 1e10c84am36(暂无匿称)

超好的文章，受益

55 0

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