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BMJ：肥大细胞瘤-案例

2016-05-21 Mechront 译 MedSci原创

肥大细胞瘤儿童肿瘤
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患者男，6个月，清洗时出现面部肿胀和烦乱，右腿3 cm × 1 cm大小的红斑病变，这个皮损从出生就存在，但是这段时间皮肤病变变的红肿，并且其内充满了液体。在摩擦时皮肤病变处会起风团。临床诊断为肥大细胞瘤。这种皮肤肥大细胞病变会引起局部瘙痒和起泡，偶尔肥大细胞释放介质而出现全身症状。其触发包括局部刺激。肥大细胞增多症以一个或多个组织异常肥大细胞积累为特点，而出现一组异质性特征，其发病率约为1/10

患者男，6个月，清洗时出现面部肿胀和烦乱，右腿3 cm × 1 cm大小的红斑病变，这个皮损从出生就存在，但是这段时间皮肤病变变的红肿，并且其内充满了液体。



在摩擦时皮肤病变处会起风团。临床诊断为肥大细胞瘤。

这种皮肤肥大细胞病变会引起局部瘙痒和起泡，偶尔肥大细胞释放介质而出现全身症状。其触发包括局部刺激。

肥大细胞增多症以一个或多个组织异常肥大细胞积累为特点，而出现一组异质性特征，其发病率约为1/10000。

肥大细胞瘤是良性的，通常在儿童期就可以解决。

原始出处：

Gorav Neel Wali, Clare Robertson, et al.Mastocytoma with systemic symptoms.BMJ 2016;353:i2763

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1848004, encodeId=da0c18480045d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Apr 27 08:49:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138131, encodeId=ae9c138131c2, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:17:33 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=90158, encodeId=7f2a9015804, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/995C0EF7B180AD1E7135186F0F0D55FB/100, createdBy=20f81734164, createdName=QQffd671b5, createdTime=Fri Jun 17 00:09:00 CST 2016, time=2016-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475798, encodeId=d93614e579862, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569169, encodeId=e17e15691696d, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=)]
    2017-04-27 gaoxiaoe

    #BMJ#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1848004, encodeId=da0c18480045d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Apr 27 08:49:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138131, encodeId=ae9c138131c2, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:17:33 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=90158, encodeId=7f2a9015804, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/995C0EF7B180AD1E7135186F0F0D55FB/100, createdBy=20f81734164, createdName=QQffd671b5, createdTime=Fri Jun 17 00:09:00 CST 2016, time=2016-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475798, encodeId=d93614e579862, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569169, encodeId=e17e15691696d, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=)]
    2016-09-30 1e10c84am36(暂无匿称)

    拜读，好文

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1848004, encodeId=da0c18480045d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Apr 27 08:49:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138131, encodeId=ae9c138131c2, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:17:33 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=90158, encodeId=7f2a9015804, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/995C0EF7B180AD1E7135186F0F0D55FB/100, createdBy=20f81734164, createdName=QQffd671b5, createdTime=Fri Jun 17 00:09:00 CST 2016, time=2016-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475798, encodeId=d93614e579862, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569169, encodeId=e17e15691696d, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=)]
    2016-06-17 QQffd671b5

    受益匪浅

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1848004, encodeId=da0c18480045d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Apr 27 08:49:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138131, encodeId=ae9c138131c2, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:17:33 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=90158, encodeId=7f2a9015804, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/995C0EF7B180AD1E7135186F0F0D55FB/100, createdBy=20f81734164, createdName=QQffd671b5, createdTime=Fri Jun 17 00:09:00 CST 2016, time=2016-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475798, encodeId=d93614e579862, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569169, encodeId=e17e15691696d, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=)]
    2016-05-23 spoonycyy

    #细胞瘤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1848004, encodeId=da0c18480045d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Apr 27 08:49:00 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138131, encodeId=ae9c138131c2, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:17:33 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=90158, encodeId=7f2a9015804, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/995C0EF7B180AD1E7135186F0F0D55FB/100, createdBy=20f81734164, createdName=QQffd671b5, createdTime=Fri Jun 17 00:09:00 CST 2016, time=2016-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475798, encodeId=d93614e579862, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569169, encodeId=e17e15691696d, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Mon May 23 00:49:00 CST 2016, time=2016-05-23, status=1, ipAttribution=)]
    2016-05-23 gds2014

    #肥大细胞#

    0

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