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Oncotarget:番红花酸或可有效抑制胰腺癌癌细胞的生长

2015-11-05 MedSci MedSci原创

Oncotarget:Crocetinic酸或可有效抑制胰腺癌癌细胞的生长近些年来,来自勘萨斯大学医学中心的癌症生物学系的研究人员一直在研究番红花酸对胰腺癌的作用。番红花酸来自藏红花,一种流行的香料和食品着色剂,是很多印度传统药物的关键成分。据发表于Oncotarget的一项新的研究表明,Crocetinic酸——从番红花酸中纯化出来的复合物,可抑制胰腺癌细胞的生长。Animesh Dhar博士说

近些年来,来自勘萨斯大学医学中心的癌症生物学系的研究人员一直在研究番红花酸对胰腺癌的作用。番红花酸来自藏红花,一种流行的香料和食品着色剂,是很多印度传统药物的关键成分。

据发表于Oncotarget的一项新的研究表明,Crocetinic酸——从番红花酸中纯化出来的复合物,可抑制胰腺癌细胞的生长。

Animesh Dhar博士说道,应用Crocetinic酸21天后,小鼠皮下的胰腺癌组织生长明显减慢。“相比于未接受Crocetinic酸治疗的小鼠,接受Crocetinic酸治疗的小鼠其癌组织的生长速度下降了75%,未接受Crocetinic酸治疗的小鼠其癌组织体积增加了250%”

胰腺癌是最致命的癌症之一,是美国群众因癌症死亡的第四大病因,每年超43000人诊断出患有胰腺癌,且每年因胰腺癌死亡的人数也约43000人。目前仅有3%的胰腺癌患者在确诊后可存活5年以上。

KU医学中心的试验表明,Crocetinic酸可靶向并抑制胰腺癌干细胞——通常可抗传统化疗药物的一群致死性的细胞。

“除非破坏这些细胞,否则癌症还可复发,” Shrikant Anant博士说道,“如果我们可以确定Crocetinic酸可成功的抑制或破坏这些干细胞,那么这将是胰腺癌治疗上的一大进步。

原始出处:

Crocetinic acid in saffron may inhibit the pancreatic cancer cell growth. Science Daily,November 2, 2015.


Rangarajan P, Subramaniam D, Paul S, Kwatra D, Palaniyandi K, Islam S, Harihar S, Ramalingam S, Gutheil W, Putty S, Pradhan R, Padhye S, Welch DR, Anant S, Dhar A. Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells. Oncotarget. 2015 Sep 29;6(29):27661-73.

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    2016-05-28 闆锋旦
  3. [GetPortalCommentsPageByObjectIdResponse(id=2061131, encodeId=ea5b2061131ca, content=<a href='/topic/show?id=ccfa6061407' target=_blank style='color:#2F92EE;'>#有效抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60614, encryptionId=ccfa6061407, topicName=有效抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Wed Jun 08 04:33:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795321, encodeId=9b881e9532138, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sat May 28 22:33:00 CST 2016, time=2016-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42677, encodeId=3d86426e722, content=胰腺癌是治疗效果最差的肿瘤之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Nov 06 19:57:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252055, encodeId=ca731252055e0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Nov 06 15:33:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42573, encodeId=4a9f425e3ea, content=可以跟踪, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Nov 05 08:12:00 CST 2015, time=2015-11-05, status=1, ipAttribution=)]
    2015-11-06 jetleo

    胰腺癌是治疗效果最差的肿瘤之一

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    2015-11-06 yxch36
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    2015-11-05 gzhjjx

    可以跟踪

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