SLEEP：阻塞性睡眠呼吸暂停和认知能力下降之间的关系

2016-02-22 QQduhp 译 MedSci原创

目标既往一些评估睡眠质量异常与认知能力下降的前瞻性数据的准确性和数量是有限的,因为大多数研究使用主观数据和/或短期随访。我们假设,在15年的随访时间中,相比睡眠正常的参与者而言，患有OSA和睡眠质量差的参与者认知功能下降更甚。方式研究人员为ARIC参与者(n=966，平均年龄为61岁,55%为女性)进行家庭式多导睡眠描记术检查(1996-1998)，并在之后15年随访中进行重复认知测试。研究人员

目标：既往一些评估睡眠质量异常与认知能力下降的前瞻性数据的准确性和数量是有限的，因为大多数研究使用主观数据和/或短期随访。我们假设，在15年的随访中，相比睡眠正常的参与者而言，患有OSA和睡眠质量差的参与者认知功能下降更甚。

方式：研究人员为ARIC参与者(n=966，平均年龄为61岁,55%为女性)进行家庭式多导睡眠描记术检查(1996-1998)，并在之后15年的随访中进行重复认知测试。研究人员在1996-1998年和2011-2013年对参与者进行了3个认知测试(单词记忆力、流畅性测验和数字符号替换)，并在2011-2013年进行了10个额外的认知功能测试。研究人员使用临床阻塞性睡眠呼吸暂停综合症病情划分标准对患者病情的严重程度进行分类，并运用多元线性回归方法探讨阻塞性睡眠呼吸暂停综合症与参与者认知功能之间的关系。

结果：两次认知功能评估历时平均14.9年(最久时间为17.3年)。研究人员发现，阻塞性睡眠呼吸暂停综合症的严重程度和睡眠指数(如血氧不足和障碍性呼吸、睡眠中断、睡眠时间缩短)等与认知功能测试的变化无关。

结论：总的来说，中年时睡眠质量和时长异常并不会导致老年时认知能力下降。但是睡眠质量和时长对老年人认知衰退的不利影响尚在研究中。

原始出处：

Pamela L. Lutsey, Lindsay G.S. Bengtson,et al.Obstructive Sleep Apnea and 15-Year Cognitive Decline: The Atherosclerosis Risk in Communities (ARIC) Study,Sleep.Feb 1,2016

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#插入话题

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2016-05-11 tomyang96

#阻塞#

48 0
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2016-07-13 zhanfl

#睡眠呼吸#

58 0
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2016-03-28 忠诚向上

好好学习一下

96 0
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2016-03-28 忠诚向上

好好学习一下

205 0
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2016-03-28 忠诚向上

好好学习一下

150 0
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2016-03-28 忠诚向上

好好学习一下

210 0
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2016-03-28 忠诚向上

好好学习一下

146 0
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2016-03-28 忠诚向上

好好学习一下

117 0
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2016-03-28 忠诚向上

好好学习一下

100 0
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2016-02-24 ms4657536712156177

#SLE#

61 0

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SLEEP：阻塞性睡眠呼吸暂停和认知能力下降之间的关系

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