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Stroke:上肢卒中后运动障碍的结构和功能相关性

2019-10-24 xing.T MedSci原创

由此可见,定量神经生理学指标的实施,例如静息运动阈值在神经康复试验中可以考虑将其作为损伤的替代指标。

许多研究试图揭示卒中后运动障碍的神经相关性,但很少有人使用多学科方法进行解释。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究的目的是通过结合电生理、解剖学和功能性神经影像学数据来阐明上肢运动障碍的神经结构和功能相关性。

研究人员纳入了40名缺血性卒中患者(中位[最小-最大]年龄:63[33-82]岁,卒中后时间:3.5[1.1-58]个月),他们单侧上肢无力。上肢运动障碍由运动综合评分来定义。简单线性分析然后进行多重线性回归分析,以找出哪些变量(皮质脊髓兴奋性、原发性运动皮层或皮质脊髓[CST]内的侧向指数以及胼胝体完整性)是最能解释上肢运动障碍的因素。 

静止的运动阈值比率与CST损伤(r=-0.50 [95%CI为-0.70至-0.22];P<0.001)以及运动诱发的电势振幅(r=-0.73,[95%CI为-0.85至-0.54];P<0.001)之间存在显著相关性。多元回归模型只有静息运动阈值比率仍然保留,并解释了卒中后上肢运动障碍一半的变异(49%;P<0.001)。

由此可见,定量神经生理学指标的实施,例如静息运动阈值在神经康复试验中可以考虑将其作为损伤的替代指标。 

原始出处:

Claire Kemlin.et al.Elucidating the Structural and Functional Correlates of Upper-Limb Poststroke Motor Impairment.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.027126

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    2019-10-24 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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