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BMJ:不要指责痛风病人“没管住嘴”!虽然这几种食物升高尿酸

2019-01-09 文韬 中国循环杂志

都说痛风是富贵病、吃出来的病。有研究发现,红肉、海鲜、喝酒、含糖饮料和与痛风发作有关。

都说痛风是富贵病、吃出来的病。有研究发现,红肉、海鲜、喝酒、含糖饮料和与痛风发作有关。

血中尿酸过多会引起痛风。尿酸由身体新陈代谢产生,从尿中排除。尿酸难溶于血,尿酸结晶进入关节后,会引痛风,导致肿胀和疼痛。

近期,英国医学杂志(BMJ)发表了一项荟萃分析,分析了饮食和血尿酸水平之间的关系,以及饮食和遗传对血尿酸的贡献。

结果发现,这几种食物可能增加尿酸,包括啤酒、白酒、葡萄酒、土豆、禽类、甜饮料和红肉(即牛肉、猪肉、羊肉)。

而鸡蛋、花生、麦片、脱脂牛奶、奶酪、黑面包、黄油、非柑橘类水果可降低尿酸水平。

但是这些食物只能解释3.28%的尿酸变化,即使是63种食品加起来,也只能解释了血尿酸水平的4.29%。

相比之下,遗传对于尿酸水平的升高,反而比食物更重要,全基因组能解释血清尿酸水平变异的23.9%。

该研究说明,饮食似乎对尿酸的影响似乎很小,而遗传的作用更大。

痛风犯了,我们指责病人“没管住嘴”似乎不太合适。也证明,用药控制尿酸水平,可能更为重要。

当然,研究有几个局限性。主要的问题是使用了食物频率问卷,这不可控的因素比较多,其次,这是一项针对健康人的研究,而非痛风患者。

研究人员总入选了超过1.6万人的数据,这些人没有痛风,也没有服用影响尿酸水平的药物。

原始出处:Major TJ, Topless RK, Dalbeth N, et al. Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts. BMJ, 2018, 363: k3951.

 

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    2021-03-02 ms1000000814206857

    学习了

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    2019-09-10 gaoxiaoe
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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:18:55 CST 2019, time=2019-01-10, status=1, ipAttribution=)]
  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:18:55 CST 2019, time=2019-01-10, status=1, ipAttribution=)]
    2019-01-10 Y—xianghai

    学习了新知识

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:18:55 CST 2019, time=2019-01-10, status=1, ipAttribution=)]
    2019-01-10 Y—xianghai

    学习了长知识

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:18:55 CST 2019, time=2019-01-10, status=1, ipAttribution=)]
    2019-01-10 Y—xianghai

    学习了长知识

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:18:55 CST 2019, time=2019-01-10, status=1, ipAttribution=)]
    2019-01-10 Y—xianghai

    学习了长知识

    0

  9. 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createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:19:12 CST 2019, time=2019-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357728, encodeId=a8b635e7283c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:19:08 CST 2019, time=2019-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357727, encodeId=b32e35e72769, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:18:55 CST 2019, time=2019-01-10, status=1, ipAttribution=)]
    2019-01-10 Y—xianghai

    学习了长知识

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Jan 10 07:18:55 CST 2019, time=2019-01-10, status=1, ipAttribution=)]
    2019-01-10 Y—xianghai

    学习了长知识

    0

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