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Sci Signal:新型机器人技术追踪癌症信号通路,及早发现癌症迹象!

2017-05-24 Heather_z727 来宝网

恶性黑色素瘤是最常见,也是最危险的癌症类型之一。日前,来自亚历山大大学研究所的研究人员使用创新机器人技术研究棕色色素痣如何以及为什么变成恶性黑色素瘤。这一发现会使未来恶性黑色素瘤的诊断变得十分容易。研究人员还强调,为了避免恶性黑色素瘤,在使用很多化妆品和面霜的时候都应该格外小心。



恶性黑色素瘤是最常见,也是最危险的癌症类型之一。日前,来自亚历山大大学研究所的研究人员使用创新机器人技术研究棕色色素痣如何以及为什么变成恶性黑色素瘤。这一发现会使未来恶性黑色素瘤的诊断变得十分容易。研究人员还强调,为了避免恶性黑色素瘤,在使用很多化妆品和面霜的时候都应该格外小心。

到目前为止,科学家只知道是哪些基因突变诱发棕色色素痣诱变为恶性色素瘤,但是对于在恶性黑色素瘤发展的过程中,蛋白质和信号通路发生了哪些变化却不得而知。在此次研究中,科学家发现在转化过程中,ADAM10信号通路被激活,这条通路是一条蛋白质链,它们就像追逐LED灯一样,从一种蛋白追逐到另一种蛋白。这种蛋白质在健康的皮肤上通常不活跃,只有在免疫反应时才会被激活,科学界认定这种蛋白质在牛皮癣,酒糟鼻和炎症关系密切,此次研究又找到 证据证明这种蛋白对于恶性黑色素瘤的影响。

在此次研究中,科学家使用一种新型的机器人,通过追踪ADAM10信号通路来观察恶性黑色素瘤的发展,这种方法可以通过相同的组织样本产生不同的图像序列,从而揭示蛋白质和细胞的活跃性,在之前的研究中,只有1至4个标记物可以被识别,而如今的新型机器人可以标记超过100个蛋白质,这使得恶性黑色素的诊断更加容易。

此次研究的完整报告发布与《科学信号》杂志中。

原始出处:

Christian Ostalecki, Jung-Hyun Lee, Jochen Dindorf, et al. Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes, Science Signaling (2017). DOI: 10.1126/scisignal.aai8288

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    2017-07-22 楚秀娟
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    2017-07-02 yaanren
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    2017-05-26 xue8602
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    2017-05-25 130****4638

    学习了谢谢分享。

    0

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