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Clinica Chimica Acta:评估中国老年蛋白尿患者肾小球滤过率和肾小管功能障碍

2019-09-22 gladiator MedSci原创

目前,尚无对中国老年人群中等白蛋白尿肾损害的发生率及临床危险因素的研究。为了阐明这一点,我们对中国社区老年人口进行了调查研究。 <span style="font-size:12.0pt;mso-bidi-font-size:14.0pt; font-family:宋体;mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;

目前,尚无对中国老年人群中等白蛋白尿肾损害的发生率及临床危险因素的研究。为了阐明这一点,我们对中国社区老年人口进行了调查研究。

本研究共纳入691名老年社区参与者。将Normoalbuminuria定义为晨尿尿白蛋白肌酐比值(ACR) < 30 毫克/克。评估老年人群的肾小球滤过率(eGFR)和尿-1微球蛋白肌酐比值(MCR),以评估正常蛋白尿肾损害。

在整个队列中,30.25%的患者有蛋白尿,8.68%的患者eGFR降低,49.78%的患者MCR升高。正常白蛋白尿受试者也表现出低eGFRMCR升高的高患病率(eGFR降低6.02%MCR升高37.55%)。在正常白蛋白尿患者中,MCR升高的患病率最高的是糖尿病患者(50%),而低eGFR的患病率最高的是女性(8.11%)normoalbuminuric之间没有显著差异。年龄、性别、糖尿病高血压均为MCR升高的独立危险因素。糖尿病高血压eGFR降低无统计学影响,而性别对eGFR降低的风险最高。

研究表明,蛋白尿作为肾损伤的筛查指标可能作用有限,因为尽管有正常蛋白尿,仍有相当比例的老年人存在肾功能损害。正常白蛋白尿肾损害不应只关注糖尿病或高血压患者,而应在整个老年人群中给予更多关注。

原始出处:

Huabin WangYingjie LouEstimating the glomerular filtration rate and tubular dysfunction in an elderly population with normoalbuminuria in China

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2020-07-03 windight
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