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ENDO 2016:想减脂肪又不想肌肉变少的男性看过来

2016-04-05 Mechront 译 MedSci原创

美国内分泌学会年会上称,肥胖和低睾酮的健康男性使用睾酮+非常低热量饮食,在减少体脂的同时,不会丢失肌肉,而安慰剂对照组在减少体脂的同时,肌肉也变少了。澳大利亚维多利亚州墨尔本大学的内分泌科Mark Ng Tang Fui博士说:“坚持非常低热量饮食虽然可以现在减少体脂,但是肌肉也会减少。但是如果对这类男性使用睾酮,就可以帮助他们在减肥的同时,维持肌肉。”Fui和同事对100名BMI≥30 kg/m

美国内分泌学会年会上称,肥胖和低睾酮的健康男性使用睾酮+非常低热量饮食,在减少体脂的同时,不会丢失肌肉,而安慰剂对照组在减少体脂的同时,肌肉也变少了。

澳大利亚维多利亚州墨尔本大学的内分泌科Mark Ng Tang Fui博士说:“坚持非常低热量饮食虽然可以现在减少体脂,但是肌肉也会减少。但是如果对这类男性使用睾酮,就可以帮助他们在减肥的同时,维持肌肉。”

Fui和同事对100名BMI≥30 kg/m²的男性进行了一项研究,参与者睾酮水平均<12 nmol/L,平均年龄53岁,平均基线BMI为37.4 kg/m²,平均体脂为45.1 kg,平均睾酮水平为7.1 nmol/L。

所有参与者进行10周的非常低热量因素(约每天600 kcal),接着进行46周的体重维持饮食(正常食物)。总共56周的时间里,研究者将参与者随机分为10周一次的1,000-mg睾酮肌肉注射组(n = 49)或安慰剂组(n = 51)。以DXA检测的脂肪质量作为主要结局,腹部CT检测的内脏脂肪质量和DXA检测的肌肉质量作为继发结局。

数据显示,在第56周,两组体重下降约为11kg,睾酮组体脂下降更多(平均绝对偏差
(MAD)为-2.9 kg),内脏脂肪也下降更多(MAD, -2,678 mm²),此外睾酮组肌肉下降更少(MAD, 3.4 kg)。

Fui指出,队列纳入的健康男性不包含手臂锻炼的人群,并且没有评估参与者的代谢结果。

澳大利亚维多利亚州墨尔本大学的Mathis Grossman副教授说:“尽管两组的体脂都有所下降,但是睾酮组肌肉下降更少,说明睾酮可以对减肥男性肌肉的减少起预防作用。接下来我们将对这些变化对代谢的影响进行研究。”

原始出处:

Ng Tang Fui M, et al. LB-OR02-1. Presented at: The Endocrine Society Annual Meeting; April 1-4, 2016; Boston.

Testosterone therapy plus very low calorie diet prevents lean mass loss in men
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  1. [GetPortalCommentsPageByObjectIdResponse(id=77497, encodeId=3170e749720, content=这样会不会有不良反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Tue Apr 12 11:47:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554962, encodeId=4f541554962be, content=<a href='/topic/show?id=d22831281d5' target=_blank style='color:#2F92EE;'>#减脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31281, encryptionId=d22831281d5, topicName=减脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cbb14571349, createdName=lujian, createdTime=Thu Apr 07 05:12:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76144, encodeId=90a4e61443c, content=关键是要坚持, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 06 22:57:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76068, encodeId=fd06e606849, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=197, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Apr 06 15:54:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=75794, encodeId=185ce579408, content=原来真的可以双赢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:22:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-12 Gsurgeon

    这样会不会有不良反应

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=77497, encodeId=3170e749720, content=这样会不会有不良反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Tue Apr 12 11:47:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554962, encodeId=4f541554962be, content=<a href='/topic/show?id=d22831281d5' target=_blank style='color:#2F92EE;'>#减脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31281, encryptionId=d22831281d5, topicName=减脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cbb14571349, createdName=lujian, createdTime=Thu Apr 07 05:12:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76144, encodeId=90a4e61443c, content=关键是要坚持, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 06 22:57:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76068, encodeId=fd06e606849, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=197, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Apr 06 15:54:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=75794, encodeId=185ce579408, content=原来真的可以双赢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:22:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-07 lujian
  3. [GetPortalCommentsPageByObjectIdResponse(id=77497, encodeId=3170e749720, content=这样会不会有不良反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Tue Apr 12 11:47:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554962, encodeId=4f541554962be, content=<a href='/topic/show?id=d22831281d5' target=_blank style='color:#2F92EE;'>#减脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31281, encryptionId=d22831281d5, topicName=减脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cbb14571349, createdName=lujian, createdTime=Thu Apr 07 05:12:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76144, encodeId=90a4e61443c, content=关键是要坚持, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 06 22:57:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76068, encodeId=fd06e606849, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=197, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Apr 06 15:54:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=75794, encodeId=185ce579408, content=原来真的可以双赢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:22:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-06 文医生

    关键是要坚持

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=77497, encodeId=3170e749720, content=这样会不会有不良反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Tue Apr 12 11:47:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554962, encodeId=4f541554962be, content=<a href='/topic/show?id=d22831281d5' target=_blank style='color:#2F92EE;'>#减脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31281, encryptionId=d22831281d5, topicName=减脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cbb14571349, createdName=lujian, createdTime=Thu Apr 07 05:12:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76144, encodeId=90a4e61443c, content=关键是要坚持, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 06 22:57:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76068, encodeId=fd06e606849, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=197, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Apr 06 15:54:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=75794, encodeId=185ce579408, content=原来真的可以双赢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:22:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-06 dhzzm

    学习了,很好

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=77497, encodeId=3170e749720, content=这样会不会有不良反应, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Tue Apr 12 11:47:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554962, encodeId=4f541554962be, content=<a href='/topic/show?id=d22831281d5' target=_blank style='color:#2F92EE;'>#减脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31281, encryptionId=d22831281d5, topicName=减脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cbb14571349, createdName=lujian, createdTime=Thu Apr 07 05:12:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76144, encodeId=90a4e61443c, content=关键是要坚持, beContent=null, objectType=article, channel=null, level=null, likeNumber=195, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Wed Apr 06 22:57:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76068, encodeId=fd06e606849, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=197, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Wed Apr 06 15:54:00 CST 2016, time=2016-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=75794, encodeId=185ce579408, content=原来真的可以双赢, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIuqOuvZLWMJ8yAVHKNPBSKWLKHx7ibIhutJv2OfnTK9MQH5jpicpw5EJTmD0M0q2wOG3CZO9wTxa9A/132, createdBy=75561684788, createdName=yilibaisha, createdTime=Wed Apr 06 09:22:00 CST 2016, time=2016-04-06, status=1, ipAttribution=)]
    2016-04-06 yilibaisha

    原来真的可以双赢

    0

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