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Diabetes Care:PWV或可评估2型糖尿病脑血管病危险

2012-11-09 沐雨译 医学论坛网

  丹麦研究者研究发现,控制良好的2型糖尿病患者的颈-股脉搏波速度(PWV)较对照组更高,并与大脑白质损伤(WML)独立相关。PWV或可作为2型糖尿病脑血管疾病危险评估的临床相关参数。该研究2012年11月5日在线发表于《糖尿病护理》(Diabetes Care)杂志。   2型糖尿病患者包括卒中在内的心脑血管事件发生率很高。在普通人群中,动脉僵硬度的增高可预测心血管事件,WML与卒中

  丹麦研究者研究发现,控制良好的2型糖尿病患者的颈-股脉搏波速度(PWV)较对照组更高,并与大脑白质损伤(WML)独立相关。PWV或可作为2型糖尿病脑血管疾病危险评估的临床相关参数。该研究2012年11月5日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  2型糖尿病患者包括卒中在内的心脑血管事件发生率很高。在普通人群中,动脉僵硬度的增高可预测心血管事件,WML与卒中危险升高相关。而在2型糖尿病患者中动脉僵硬度是否与WML相关尚不清楚。因此,研究者对89例新诊断的2型糖尿病患者进行了分析,动脉僵硬度通过颈-股PWV来评估,WML通过磁共振成像检测,并使用Breteler量表分级。

  分析表明,该研究的糖尿病患者血糖控制良好,中位糖化血红蛋白(HbA1c)为6.5%,与对照组相比,总胆固醇和工作场所血压更低。此外,糖尿病患者的PWV显著高于对照组(9.3±2.0对8.0±1.6 m/s;P<0.0001)。PWV与Breteler评分和WML面积显著相关。校正年龄、性别、糖尿病、24小时平均动脉血压、体质指数(BMI)、心率和降压药及他汀的使用后,上述相关性仍然存在。

  链接:

Laugesen E, Høyem P, Stausbøl-Grøn B, Mikkelsen A, Thrysøe S, Erlandsen M, Christiansen JS, Knudsen ST, Hansen KW, Kim WY, Hansen TK, Poulsen PL.Carotid-Femoral Pulse Wave Velocity Is Associated With Cerebral White Matter Lesions in Type 2.Diabetes Care. 2012 Nov 5

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